1.
|
How complex are the rules by which a protein’s sequence determines its function? High-order epistatic interactions among residues are thought to be pervasive, suggestin [...]
11 September 2024 |
Ecology and Evolution; Genetics, Genomics, and Systems Biology; Human Genetics |
Article |
|
2.
|
Intervention efforts against falciparum malaria in high-transmission regions remain challenging, with rapid resurgence typically following their relaxation. Such resilien [...]
26 August 2024 |
Genetics, Genomics, and Systems Biology |
Article |
|
3.
|
Human cytomegalovirus (CMV) is a highly prevalent herpesvirus that is often transmitted to the neonate via breast milk. Postnatal CMV transmission can have negative healt [...]
23 July 2024 |
Genetics, Genomics, and Systems Biology; Medicine; Molecular Metabolism and Nutrition |
Article |
|
4.
|
Multicellular organisms are capable of generating a wide range of different cell types from the same genome through differentiation, during which distinct gene expression [...]
2024-08 |
Genetics, Genomics, and Systems Biology |
Dissertation |
|
5.
|
A protein’s genetic architecture – the set of causal rules by which its sequence produces its functions – also determines its possible evolutionary trajectories. Pr [...]
20 May 2024 |
Biochemistry and Molecular Biology; Biophysical Sciences; Ecology and Evolution; Genetics, Genomics, and Systems Biology; Human Genetics |
Article |
|
6.
|
Antituberculosis drugs, mostly developed over 60 years ago, combined with a poorly effective vaccine, have failed to eradicate tuberculosis. More worryingly, multiresista [...]
29 April 2024 |
Genetics, Genomics, and Systems Biology; Immunology; Medicine |
Article |
|
7.
|
Nearly all trait-associated variants identified in genome-wide association studies (GWASs) are noncoding. The cis regulatory effects of these variants have been extensive [...]
01 April 2024 |
Genetics, Genomics, and Systems Biology; Human Genetics; Medicine |
Article |
|
8.
|
Cells must sense and respond to sudden maladaptive environmental changes—stresses—to survive and thrive. Across eukaryotes, stresses such as heat shock trigger conser [...]
11 April 2024 |
Biochemistry and Molecular Biology; Biophysical Sciences; Genetics, Genomics, and Systems Biology; Medicine |
Article |
|
9.
|
Despite the recognized gut-brain axis link, natural variations in microbial profiles between patients hinder definition of normal abundance ranges, confounding the impact [...]
10 April 2024 |
Genetics, Genomics, and Systems Biology; Medicine; Pediatrics; Quantitative Methods in Social, Behavioral, and Health Sciences |
Article |
|
10.
|
Humans exhibit considerable variability in their immune responses to the same immune challenges. Such variation is widespread and affects individual and population-level [...]
05 April 2024 |
Genetics, Genomics, and Systems Biology; Human Genetics; Immunology; Medicine |
Article |
|
11.
|
Organisms use a variety of strategies to adapt to their environments and maximize long-term growth potential, but quantitative characterization of the benefits conferred [...]
17 February 2015 |
Genetics, Genomics, and Systems Biology |
Article |
|
12.
|
The vast diversity of mammalian adaptive antigen receptors allows for robust and efficient immune responses against a wide number of pathogens. The antigen receptor reper [...]
04 March 2024 |
Genetics, Genomics, and Systems Biology; Immunology; Microbiology |
Article |
|
13.
|
In the past 15 years, genome-wide association studies (GWAS) have identified thousands of genetic variants associated with a plethora of human complex traits, and greatly [...]
2024-03 |
Genetics, Genomics, and Systems Biology |
Dissertation |
|
14.
|
Importance: Veterans from recent and past conflicts have high rates of posttraumatic stress disorder (PTSD). Adaptive testing strategies can increase accuracy of diagn [...]
08 July 2021 |
Computer Science; Genetics, Genomics, and Systems Biology; Medicine; Quantitative Methods in Social, Behavioral, and Health Sciences |
Article |
|
15.
|
The acquisition of malaria immunity is both remarkably slow and unpredictable. At present, we know little about the malaria parasite genes that influence the host’s abi [...]
05 February 2020 |
Genetics, Genomics, and Systems Biology |
Article |
|
16.
|
Here, we develop digital biomarkers for autism spectrum disorder (ASD), computed from patterns of past medical encounters, identifying children at high risk with an area [...]
06 October 2021 |
Genetics, Genomics, and Systems Biology; Medicine; Pediatrics; Quantitative Methods in Social, Behavioral, and Health Sciences |
Article |
|
17.
|
Oxysterols are oxidation products of cholesterol. Cholestane-3β, 5α, 6β-triol (abbreviated as triol) is one of the most abundant and active oxysterols. Here, we report [...]
13 June 2013 |
Accounting; Ben May Department for Cancer Research; Genetics, Genomics, and Systems Biology |
Article |
|
18.
|
First-generation interaction maps of Src homology 2 (SH2) domains with receptor tyrosine kinase (RTK) phosphosites have previously been generated using protein microar [...]
04 September 2012 |
Ben May Department for Cancer Research; Cancer Biology; Genetics, Genomics, and Systems Biology |
Article |
|
19.
|
Transcription factor binding site(s) (TFBS) gain and loss (i.e., turnover) is a well-documented feature of cis-regulatory module (CRM) evolution, yet little attention [...]
28 April 2011 |
Ecology and Evolution; Genetics, Genomics, and Systems Biology |
Article |
|
20.
|
The gut microbiome interacts with the host through complex networks that affect physiology and health outcomes. It is becoming clear that these interactions can be measur [...]
02 January 2024 |
Genetics, Genomics, and Systems Biology; Medicine |
Article |
|
21.
|
Emerin is an integral membrane protein of the inner nuclear membrane. Mutations in emerin cause X-linked Emery-Dreifuss muscular dystrophy (EDMD), a disease characteri [...]
11 May 2012 |
Genetics, Genomics, and Systems Biology; Medicine |
Article |
|
22.
|
Annotating and interpreting the results of genome-wide association studies (GWAS) remains challenging. Assigning function to genetic variants as expression quantitativ [...]
03 April 2014 |
Ben May Department for Cancer Research; Clinical Pharmacology and Pharmacogenomics; Genetics, Genomics, and Systems Biology; Human Genetics; Medicine |
Article |
|
23.
|
Synonymous relationships among biomedical terms are extensively annotated within specialized terminologies, implying that synonymy is important for practical computati [...]
25 September 2014 |
Genetics, Genomics, and Systems Biology; Sociology |
Article |
|
24.
|
Bisulfite sequencing (BS-seq) to detect 5-methylcytosine (5mC) is limited by lengthy reaction times, severe DNA damage, overestimation of 5mC level and incomplete C-to-U [...]
02 January 2024 |
Biochemistry and Molecular Biology; Chemistry; Genetics, Genomics, and Systems Biology |
Article |
|
25.
|
Macrophages populate the embryo early in gestation, but their role in development is not well defined. In particular, specification and function of macrophages in intesti [...]
26 December 2023 |
Genetics, Genomics, and Systems Biology |
Article |
|