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1.
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Cells must sense and respond to sudden maladaptive environmental changes—stresses—to survive and thrive. Across eukaryotes, stresses such as heat shock trigger conser [...]
11 April 2024 |
Biochemistry and Molecular Biology; Biophysical Sciences; Genetics, Genomics, and Systems Biology; Medicine |
Article |
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2.
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Despite the recognized gut-brain axis link, natural variations in microbial profiles between patients hinder definition of normal abundance ranges, confounding the impact [...]
10 April 2024 |
Genetics, Genomics, and Systems Biology; Medicine; Pediatrics; Quantitative Methods in Social, Behavioral, and Health Sciences |
Article |
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3.
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Humans exhibit considerable variability in their immune responses to the same immune challenges. Such variation is widespread and affects individual and population-level [...]
05 April 2024 |
Genetics, Genomics, and Systems Biology; Human Genetics; Immunology; Medicine |
Article |
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4.
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Organisms use a variety of strategies to adapt to their environments and maximize long-term growth potential, but quantitative characterization of the benefits conferred [...]
17 February 2015 |
Genetics, Genomics, and Systems Biology |
Article |
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5.
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The vast diversity of mammalian adaptive antigen receptors allows for robust and efficient immune responses against a wide number of pathogens. The antigen receptor reper [...]
04 March 2024 |
Genetics, Genomics, and Systems Biology; Immunology; Microbiology |
Article |
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6.
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In the past 15 years, genome-wide association studies (GWAS) have identified thousands of genetic variants associated with a plethora of human complex traits, and greatly [...]
2024-03 |
Genetics, Genomics, and Systems Biology |
Dissertation |
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7.
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<p>Importance: Veterans from recent and past conflicts have high rates of posttraumatic stress disorder (PTSD). Adaptive testing strategies can increase accuracy of [...]
08 July 2021 |
Computer Science; Genetics, Genomics, and Systems Biology; Medicine; Quantitative Methods in Social, Behavioral, and Health Sciences |
Article |
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8.
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The acquisition of malaria immunity is both remarkably slow and unpredictable. At present, we know little about the malaria parasite genes that influence the host’s abi [...]
05 February 2020 |
Genetics, Genomics, and Systems Biology |
Article |
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9.
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Here, we develop digital biomarkers for autism spectrum disorder (ASD), computed from patterns of past medical encounters, identifying children at high risk with an area [...]
06 October 2021 |
Genetics, Genomics, and Systems Biology; Medicine; Pediatrics; Quantitative Methods in Social, Behavioral, and Health Sciences |
Article |
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10.
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Oxysterols are oxidation products of cholesterol. Cholestane-3β, 5α, 6β-triol (abbreviated as triol) is one of the most abundant and active oxysterols. Here, we report [...]
13 June 2013 |
Accounting; Ben May Department for Cancer Research; Genetics, Genomics, and Systems Biology |
Article |
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11.
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<p>First-generation interaction maps of Src homology 2 (SH2) domains with receptor tyrosine kinase (RTK) phosphosites have previously been generated using protein m [...]
04 September 2012 |
Ben May Department for Cancer Research; Cancer Biology; Genetics, Genomics, and Systems Biology |
Article |
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12.
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<p>Transcription factor binding site(s) (TFBS) gain and loss (i.e., turnover) is a well-documented feature of cis-regulatory module (CRM) evolution, yet little atte [...]
28 April 2011 |
Ecology and Evolution; Genetics, Genomics, and Systems Biology |
Article |
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13.
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The gut microbiome interacts with the host through complex networks that affect physiology and health outcomes. It is becoming clear that these interactions can be measur [...]
02 January 2024 |
Genetics, Genomics, and Systems Biology; Medicine |
Article |
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14.
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<p>Emerin is an integral membrane protein of the inner nuclear membrane. Mutations in emerin cause X-linked Emery-Dreifuss muscular dystrophy (EDMD), a disease char [...]
11 May 2012 |
Genetics, Genomics, and Systems Biology; Medicine |
Article |
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15.
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<p>Annotating and interpreting the results of genome-wide association studies (GWAS) remains challenging. Assigning function to genetic variants as expression quant [...]
03 April 2014 |
Ben May Department for Cancer Research; Clinical Pharmacology and Pharmacogenomics; Genetics, Genomics, and Systems Biology; Human Genetics; Medicine |
Article |
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16.
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<p>Synonymous relationships among biomedical terms are extensively annotated within specialized terminologies, implying that synonymy is important for practical com [...]
25 September 2014 |
Genetics, Genomics, and Systems Biology; Sociology |
Article |
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17.
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Bisulfite sequencing (BS-seq) to detect 5-methylcytosine (5mC) is limited by lengthy reaction times, severe DNA damage, overestimation of 5mC level and incomplete C-to-U [...]
02 January 2024 |
Biochemistry and Molecular Biology; Chemistry; Genetics, Genomics, and Systems Biology |
Article |
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18.
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Macrophages populate the embryo early in gestation, but their role in development is not well defined. In particular, specification and function of macrophages in intesti [...]
26 December 2023 |
Genetics, Genomics, and Systems Biology |
Article |
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19.
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<p>DNA methylation is an important epigenetic regulator of gene expression. Recent studies have revealed widespread associations between genetic variation and methy [...]
18 September 2014 |
Genetics, Genomics, and Systems Biology; Human Genetics |
Article |
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20.
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<p>Background: <em>Drosophila</em> female germline stem cells (GSCs) reside adjacent to a cellular niche that secretes Bone Morphogenetic Protein (BMP) [...]
03 July 2012 |
Development, Regeneration, and Stem Cell Biology; Genetics, Genomics, and Systems Biology; Molecular Genetics and Cell Biology |
Article |
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21.
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<p>The gene mutated in Bloom's syndrome, <em>BLM</em>, is important in the repair of damaged replication forks, and it has both pro- and anti-recombinog [...]
01 December 2009 |
Genetics, Genomics, and Systems Biology; Medicine |
Article |
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22.
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The N6-methyladenosine (m6A) methylation, identified in the 1970s, has become increasingly understood with the development of recent high-throughput sequencing techniques [...]
2023-12 |
Genetics, Genomics, and Systems Biology |
Dissertation |
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23.
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Parts-based representations, such as non-negative matrix factorization and topic modeling, have been used to identify structure from single-cell sequencing data sets, in [...]
19 October 2023 |
Genetics, Genomics, and Systems Biology; Human Genetics; Medicine; Statistics |
Article |
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24.
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While comparative functional genomic studies have shown that inter-species differences in gene expression can be explained by corresponding inter-species differences in g [...]
17 February 2021 |
Genetics, Genomics, and Systems Biology; Human Genetics; Medicine |
Article |
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25.
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Viral infection is usually studied at the population level by averaging over millions of cells. However, infection at the single-cell level is highly heterogeneous, with [...]
15 May 2019 |
Genetics, Genomics, and Systems Biology |
Article |
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