Computational Neuroscience

Motion is an essential component of everyday tactile experience: most manual interactions involve relative movement between the skin and objects. Much of the research on [...]

Drosophila’s innate response to gravity, geotaxis, has been used to assess the impact of aging and disease on motor performance. Despite its rich history, fly geotaxis co [...]

The nervous system enables precise, skilled movements across diverse contexts, consistently performed day after day. However, the extent to which the brain's neural activ [...]

Tactile feedback from brain-controlled bionic hands can be partially restored via intracortical microstimulation (ICMS) of the primary somatosensory cortex. In ICMS, the [...]

Prehensile arms are among the most remarkable features of the octopus, but little is known about the neural circuitry controlling arm movements. Here, we report on the ce [...]

Traditionally, the transfer of information between cortical areas has been attributed to direct monosynaptic projections. However, there is a growing recognition that [...]

Everything that the brain sees must first be encoded by the retina, which maintains a reliable representation of the visual world in many different, complex natural scene [...]

Intracortical microstimulation (ICMS) is a method for restoring sensation to people with paralysis as part of a bidirectional brain–computer interface (BCI) to restore up [...]

Mechanisms of computation in sensorimotor cortex must be flexible and robust to support skilled motor behavior. Patterns of neuronal coactivity emerge as a result of comp [...]

Time-order error, a psychophysical phenomenon in which the duration in between successive stimuli alters perception, has been studied for decades by neuroscientists and p [...]

In Paris, France, December 2015, the Conference of the Parties (COP) to the United Nations Framework Convention on Climate Change (UNFCCC) invited the Intergovernmental P [...]

The importance of sensation in motor control is often under-appreciated despite the severe deficits that occur when that signal is lost. Thus, restoring sensation in bion [...]

Dendritic mechanisms driving input-output transformation in starburst amacrine cells (SACs) are not fully understood. Here, we combine two-photon subcellular voltage and [...]

Glyoxalase 1 (Glo1) has been implicated in anxiety-like behavior in mice and in multiple psychiatric diseases in humans. We used mouse Affymetrix exon arrays [...]

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Microsaccades, the tiny gaze relocations that occurr during fixation, have been linked to covert attention deployed degrees away from the center of gaze. However, the lin [...]

When multiple stimuli appear together in the receptive field of a visual cortical neuron, the response is typically close to the average of that neuron’s response to ea [...]

Everything that the brain sees must first be encoded by the retina, which maintains a reliable representation of the visual world in many different, complex natural scene [...]

The underlying mechanisms of computation in sensorimotor cortex must be both flexibleand robust to support the range of skilled, dynamic forelimb movements observed in na [...]

Previously, we found that in the mammalian retina, inhibitory inputs onto starburst amacrine cells (SACs) are required for robust direction selectivity of On-Off directio [...]

Low-dimensional linear dynamics are observed in neuronal population activity in primary motor cortex (M1) when monkeys make reaching movements. This population-level beha [...]

How circuits self-assemble starting from neuronal stem cells is a fundamental question in developmental neurobiology. Here, we addressed how neurons from different stem c [...]

The primary motor cortex has been shown to coordinate movement preparation and execution through computations in approximately orthogonal subspaces. The underlying networ [...]

In the somatosensory nerves, the tactile perception of texture is driven by spatial and temporal patterns of activation distributed across three populations of afferents. [...]

The primary motor (M1) and somatosensory (S1) cortices play critical roles in motor control but the signaling between these structures is poorly understood. To fill this [...]