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1.
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Organisms use a variety of strategies to adapt to their environments and maximize long-term growth potential, but quantitative characterization of the benefits conferred [...]
17 February 2015 |
Genetics, Genomics, and Systems Biology |
Article |
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2.
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There is growing evidence that prenatal immune activation contributes to neuropsychiatric disorders. Here, we show that early postnatal immune activation resulted in prof [...]
17 September 2021 |
Human Genetics; Medicine |
Article |
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3.
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Infected cells communicate through secreted signaling molecules like cytokines, which carry information about pathogens. How differences in cytokine secretion affect infl [...]
31 August 2022 |
Institute for Genomics and Systems Biology |
Article |
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4.
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Individual cells are heterogeneous when responding to environmental cues. Under an external signal, certain cells activate gene regulatory pathways, while others complete [...]
22 October 2021 |
Institute for Genomics and Systems Biology |
Article |
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5.
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Dynamical control of cellular microenvironments is highly desirable to study complex processes such as stem cell differentiation and immune signaling. We present an ultra [...]
03 April 2019 |
Institute for Genomics and Systems Biology |
Article |
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6.
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Polyphosphate is a ubiquitous linear homopolymer of phosphate residues linked by high-energy bonds similar to those found in ATP. It has been associated with many proc [...]
28 January 2011 |
Ecology and Evolution |
Article |
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7.
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Background: Cellular hypoxia, if severe enough, results usually in injury or cell death. Our research in this area has focused on the molecular mechanisms underlying h [...]
30 May 2007 |
Ecology and Evolution; Human Genetics |
Article |
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8.
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The major histocompatibility complex (MHC) region is strongly associated with multiple sclerosis (MS) susceptibility. HLA-DRB1*15:01 has the stronges [...]
21 November 2013 |
Medicine |
Article |
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9.
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Bacteria prudently regulate their metabolic phenotypes by sensing the availability of specific nutrients, expressing the required genes for their metabolism, and repressi [...]
25 September 2014 |
Institute for Genomics and Systems Biology |
Article |
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10.
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Because there is considerable variation in gene expression even between closely related species, it is clear that gene regulatory mechanisms evolve relatively rapidly. [...]
26 June 2014 |
Ecology and Evolution |
Article |
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11.
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To ensure long-term reproductive success organisms have to cope with harsh environmental extremes. A reproductive strategy that simply maximizes offspring production i [...]
28 August 2014 |
Ecology and Evolution; Organismal Biology and Anatomy |
Article |
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12.
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Transcriptional control of gene regulation is an intricate process that requires precise orchestration of a number of molecular components. Studying its evolution can [...]
25 July 2011 |
Ecology and Evolution |
Article |
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13.
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Phenotypes that appear to be conserved could be maintained not only by strong purifying selection on the underlying genetic systems, but also by stabilizing selection [...]
20 September 2012 |
Ecology and Evolution; Organismal Biology and Anatomy |
Article |
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14.
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Different functional constraints contribute to different evolutionary rates across genomes. To understand why some sequences evolve faster than others in a single [...]
02 June 2011 |
Ecology and Evolution; Organismal Biology and Anatomy |
Article |
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15.
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The regulatory logic of time- and tissue-specific gene expression has mostly been dissected in the context of the smallest DNA fragments that, when isolated, recapitul [...]
10 November 2011 |
Ecology and Evolution; Human Genetics |
Article |
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16.
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Sediment microbial communities are responsible for a majority of the metabolic activity in river and stream ecosystems. Understanding the dynamics in community structu [...]
19 May 2014 |
Biophysical Sciences; Ecology and Evolution; Geophysical Sciences |
Article |
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17.
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Objective: To determine the genetic contribution to leukocyte endothelial adhesion. Methods: Leukocyte endothelial adhesion was assessed through a novel cell-bas [...]
10 February 2014 |
Medicine |
Article |
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18.
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Perennial questions of evolutionary biology can be applied to gene regulatory systems using the abundance of experimental data addressing gene regulation in a comparat [...]
19 January 2012 |
Ecology and Evolution; Organismal Biology and Anatomy |
Article |
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19.
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Variation in gene expression has been observed in natural populations and associated with complex traits or phenotypes such as disease susceptibility and drug response [...]
21 October 2010 |
Clinical Pharmacology and Pharmacogenomics; Human Genetics; Medicine; Public Health Sciences |
Article |
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20.
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Annotating and interpreting the results of genome-wide association studies (GWAS) remains challenging. Assigning function to genetic variants as expression quantitativ [...]
03 April 2014 |
Ben May Department for Cancer Research; Clinical Pharmacology and Pharmacogenomics; Genetics, Genomics, and Systems Biology; Human Genetics; Medicine |
Article |
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21.
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Background: Cancer staging and treatment presumes a division into localized or metastatic disease. We proposed an intermediate state defined by ≤5 cumulative metasta [...]
13 December 2011 |
Cancer Biology; Pathology; Radiation and Cellular Oncology; Surgery |
Article |
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22.
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The Yorkie/Yap transcriptional coactivator is a well-known regulator of cellular proliferation in both invertebrates and mammals. As a coactivator, Yorkie (Yki) lacks [...]
05 September 2013 |
Human Genetics |
Article |
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23.
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Behavior is among the most dynamic animal phenotypes, modulated by a variety of internal and external stimuli. Behavioral differences are associated with large-scale c [...]
29 March 2012 |
Human Genetics |
Article |
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24.
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The discovery of expression quantitative trait loci (“eQTLs”) can help to unravel genetic contributions to complex traits. We identified genetic determinants of hu [...]
26 May 2011 |
Clinical Pharmacology and Pharmacogenomics; Ecology and Evolution; Medicine |
Article |
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25.
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Many colonic mucosal genes that are highly regulated by microbial signals are differentially expressed along the rostral-caudal axis. This would suggest that differenc [...]
22 October 2010 |
Medicine; Pathology |
Article |
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