Center for Clinical Cancer Genetics and Global Health

Importance: Triple-negative breast cancer (TNBC) disproportionately affects Black women. Immunotherapy improves outcomes in early-stage TNBC (esTNBC) and metastatic TN [...]

Protein activity state, rather than protein or mRNA abundance, is a biologically regulated and relevant input to many processes in signaling, differentiation, development [...]

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Importance: There has been little consideration of genomic risk of recurrence by breast cancer subtype despite evidence of racial disparities in breast cancer outcomes [...]

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We used an approach that we term ancestry-shift refinement mapping to investigate an association, originally discovered in a GWAS of a Chinese population, between rs20462 [...]

Single Nucleotide Polymorphisms (SNPs) in genes involved in the DNA Base Excision Repair (BER) pathway could be associated with cancer risk in carriers of mutations in th [...]

The considerable uncertainty regarding cancer risks associated with inherited mutations of BRCA2 is due to unknown factors. To investigate whether c [...]

Background: Previous work in European ancestry populations has shown that adding a polygenic risk score (PRS) to breast cancer risk prediction models based on epidemio [...]

Background: Alcohol drinking is linked to the development of breast cancer. However, there is little knowledge about the impact of alcohol consumption on breast cancer [...]

Genetic variants in hormone receptor genes may be crucial predisposing factors for breast cancer, and microsatellites in the estrogen receptor (ESR1, ESR2 [...]

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GW [...]

Genome-wide association studies (GWAS) have identified >300 loci associated with measures of adiposity including body mass index (BMI) and waist-to-hip ratio (adjusted [...]

Genome wide association studies (GWAS) have identified low penetrance and high frequency single nucleotide polymorphisms (SNPs) that contribute to genetic susceptibility [...]

Funding: Susan G. Komen ® GTDR16376189 Objective: To estimate the effect health system engagement on a woman’s awareness of and decision to complete a genetic test to [...]

Objective: To estimate the effect health system engagement on a woman’s awareness of and decision to complete a genetic test to predict cancer risk. Background: Young A [...]

Objective: To conduct a series of multi-level regression models to identify any association between wind turbines and cancer incidence between counties, within counties o [...]

Abstract African American women are both more likely to develop and die from Triple Negative Breast Cancer than their white counterparts. Concurrently, African American w [...]