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1.
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Genome instability is a hallmark of cancer, resulting in the accumulation of various types of alterations. Somatic structural variations (SVs) in cancer can shuffle DNA c [...]
2024-12 |
Cancer Biology |
Dissertation |
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2.
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Immune stimulating agents like Toll-like receptor 7 (TLR7) agonists induce potent antitumor immunity but are limited in their therapeutic window due to off-target immune [...]
07 October 2022 |
Ben May Department for Cancer Research; Cancer Biology; Immunology |
Article |
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3.
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When talking about cancer, a lot of hallmarks can picture it, such as self-sufficiency in growth signals, evading apoptosis, invasion, and metastasis, and so on. However, [...]
2024-06 |
Cancer Biology |
Dissertation |
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4.
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In the context of developmental biology, puberty emerges as a critical "window of susceptibility," marking a pivotal phase in which the mammary gland undergoes [...]
2024-06 |
Cancer Biology |
Dissertation |
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5.
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This three-parts thesis presents discovery of the molecular mechanisms underpinning hematopoiesis and its dysregulation in cancer. Identifying tumor suppressor genes [...]
2024-06 |
Cancer Biology |
Dissertation |
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6.
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Individuals with a loss-of-function single nucleotide polymorphism in the gene encoding PTPN22 have an increased risk for autoimmune diseases, and cancer patients with su [...]
2024-06 |
Cancer Biology |
Dissertation |
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7.
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CUX1 is a homeodomain-containing transcription factor that is essential for the development and differentiation of multiple tissues. CUX1 is recurrently mutated or delete [...]
11 May 2024 |
Cancer Biology; Molecular Genetics and Cell Biology; Pathology; Pediatrics |
Article |
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8.
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Commensal microbes have the capacity to affect development and severity of autoimmune diseases. Germ-free (GF) animals have proven to be a fine tool to obtain definitive [...]
08 May 2024 |
Cancer Biology; Immunology; Microbiology; Pathology |
Article |
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9.
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Metabolism, a fundamental aspect of all biological systems, encompasses the intricate network of chemical reactions that occur within a living organism to maintain life. [...]
2024-03 |
Cancer Biology |
Dissertation |
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10.
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The revolutionizing efficacy of recombinant human bone morphogenetic protein (rhBMP-2) for clinical spinal fusion is hindered by safety issues associated with the high do [...]
11 June 2021 |
Cancer Biology; Immunology; Radiology |
Article |
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11.
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Hepatic steatosis is a major etiological factor in hepatocellular carcinoma (HCC), but factors causing lipid accumulation leading to HCC are not understood. We identify B [...]
12 October 2022 |
Ben May Department for Cancer Research; Cancer Biology; Molecular Metabolism and Nutrition |
Article |
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12.
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First-generation interaction maps of Src homology 2 (SH2) domains with receptor tyrosine kinase (RTK) phosphosites have previously been generated using protein microar [...]
04 September 2012 |
Ben May Department for Cancer Research; Cancer Biology; Genetics, Genomics, and Systems Biology |
Article |
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13.
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Background: Mutations in the SF3B1 splicing factor are commonly seen in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), yet the specific oncogenic pa [...]
30 August 2022 |
Cancer Biology; Medicine |
Article |
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14.
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The phosphoinositol-3 kinase (PI3K) pathway is highly dysregulated in squamous cell carcinoma of the head and neck (SCCHN). While inhibitors of the PI3K/AKT pathway ar [...]
05 March 2014 |
Ben May Department for Cancer Research; Cancer Biology; Medicine |
Article |
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15.
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Background: Cancer staging and treatment presumes a division into localized or metastatic disease. We proposed an intermediate state defined by ≤5 cumulative metasta [...]
13 December 2011 |
Cancer Biology; Pathology; Radiation and Cellular Oncology; Surgery |
Article |
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16.
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Nutrient stress in the tumor microenvironment (TME) requires cancer cells to adopt adaptive metabolic programs for survival and proliferation. Therefore, knowledge of mic [...]
2023-12 |
Cancer Biology |
Dissertation |
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17.
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Cancer immunotherapy is moving toward combination regimens with agents of complementary mechanisms of action to achieve more frequent and robust efficacy. However, compar [...]
29 November 2023 |
Ben May Department for Cancer Research; Cancer Biology; Immunology |
Article |
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18.
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The molecular roles of HOX transcriptional activity in human prostate epithelial cells remain unclear, impeding the implementation of new treatment strategies for cancer [...]
18 June 2020 |
Cancer Biology; Surgery |
Article |
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19.
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Observing the structure and regeneration of the myelin sheath in peripheral nerves following injury and during repair would help in understanding the pathogenesis and tre [...]
14 October 2019 |
Cancer Biology; Surgery |
Article |
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20.
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Lysosomes adopt dynamic, tubular states that regulate antigen presentation, phagosome resolution, and autophagy. Tubular lysosomes are studied either by inducing autophag [...]
04 October 2021 |
Ben May Department for Cancer Research; Cancer Biology; Chemistry |
Article |
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21.
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Non-healing wounds have a negative impact on quality of life and account for many cases of amputation and even early death among patients. Diabetic patients are the predo [...]
11 September 2023 |
Cancer Biology; Immunology; Molecular Metabolism and Nutrition |
Article |
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22.
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Provided herein are peptide-based therapeutics that target FOXP3 and methods of use thereof to decrease the immunosuppressive effects of Tregs and inhibit immune dysregul [...]
01 April 2021 |
Medicine; Cancer Biology |
Patent |
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23.
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Methods and compositions for treating cancer are disclosed.
08 April 2021 |
Cancer Biology; Ben May Department for Cancer Research; Pathology; Biological Sciences; Medicine |
Patent |
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24.
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Disclosed are binding proteins, or fragments thereof, that specifically binds to a cancer-specific glycosylation variant of a protein and to a second epitope on the same [...]
25 May 2017 |
Cancer Biology; Pathology |
Patent |
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25.
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Described herein are methods for treating breast cancer and for providing a prognosis for metastatic-free survival of breast cancer patients. Aspects relate to treating a [...]
19 April 2018 |
Development, Regeneration, and Stem Cell Biology; Ben May Department for Cancer Research; Cancer Biology |
Patent |
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