Provided herein are peptide-based therapeutics that target FOXP3 and methods of use thereof to decrease the immunosuppressive effects of Tregs and inhibit immune dysregulation, while sparring inhibition of activated cytotoxic T cells, for example, in the context of anti-tumor immune responses, autoimmunity, inflammatory conditions, etc.
Details
Title
COMPOSITIONS AND METHODS FOR INHIBITION OF FOXP3
Inventors
Labelle, James : University of Chicago Eclov, Rachel : University of Chicago Bird, Gregory : Dana-Farber Cancer Institute Walensky, Loren D. : Dana-Farber Cancer Institute
Applicants
University of Chicago Dana Farber Cancer Institute Inc.
Content Type
Patent
Assignees
Dana-Farber Cancer Institute Inc. University of Chicago
