Background: Cancer staging and treatment presumes a division into localized or metastatic disease. We proposed an intermediate state defined by ≤5 cumulative metastasis(es), termed oligometastases. In contrast to widespread polymetastases, oligometastatic patients may benefit from metastasis-directed local treatments. However, many patients who initially present with oligometastases progress to polymetastases. Predictors of progression could improve patient selection for metastasis-directed therapy.
Methods: Here, we identified patterns of microRNA expression of tumor samples from oligometastatic patients treated with high-dose radiotherapy.
Results: Patients who failed to develop polymetastases are characterized by unique prioritized features of a microRNA classifier that includes the microRNA-200 family. We created an oligometastatic-polymetastatic xenograft model in which the patient-derived microRNAs discriminated between the two metastatic outcomes. MicroRNA-200c enhancement in an oligometastatic cell line resulted in polymetastatic progression.
Conclusions: These results demonstrate a biological basis for oligometastases and a potential for using microRNA expression to identify patients most likely to remain oligometastatic after metastasis-directed treatment.
Details
Title
MicroRNA Expression Characterizes Oligometastasis(es)
Author
Lussier, Yves A. : University of Chicago Xing, H. Rosie : University of Chicago Salama, Joseph K. : Duke University Medical Center Khodarev, Nikolai N. : University of Chicago Huang, Yong : University of Chicago University of Chicago : University of Chicago Khan, Sajid A. : University of Chicago Yang, Xinan : University of Chicago Hasselle, Michael D. : University of Chicago Darga, Thomas E. : University of Chicago Malik, Renuka : University of Chicago Fan, Hanli : University of Chicago Perakis, Samantha : University of Chicago Filippo, Matthew : University of Chicago Corbin, Kimberly : University of Chicago Lee, Younghee : University of Chicago Posner, Mitchell C. : University of Chicago Chmura, Steven J. : University of Chicago
Funding Information
Ludwig Center for Metastasis Research Center for Radiation Therapy Chicago Tumor Institute Dr. Lloyd Old Mr. and Mrs. Vincent Foglia Foglia foundation Lung Cancer Research Foundation Cancer Research Foundation National Institutes of Health, K22 LM008308-04 National Institutes of Health, 5UL1RR024999-04 University of Chicago, Comprehensive Cancer Center, 5P30CA014599-35 National Center for the Multi Scale Analysis of Genomic and Cellular Networks, 5U54CA121852-5
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