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1.
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The activation of the stimulator of interferon genes (STING) protein by cyclic dinucleotide metabolites plays a critical role in antitumor immunity. However, synthetic ST [...]
07 October 2024 |
Chemistry[...] |
Article |
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2.
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Cholesterol is an essential membrane component, and the metabolites from cholesterol play important biological functions to intricately support cancer progression and dam [...]
15 August 2024 |
Article |
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3.
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The efficacy of radiotherapy (RT) is limited by inefficient X-ray absorption and reactive oxygen species generation, upregulation of immunosuppressive factors, and a redu [...]
10 September 2024 |
Chemistry; Radiation and Cellular Oncology |
Article |
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4.
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The performance of photodynamic therapy (PDT) depends on the solubility, pharmacokinetic behaviors, and photophysical properties of photosensitizers (PSs). However, highl [...]
23 August 2021 |
Chemistry; Radiation and Cellular Oncology |
Article |
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5.
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Abnormal cancer metabolism causes hypoxic and immunosuppressive tumor microenvironment (TME), which limits the antitumor efficacy of photodynamic therapy (PDT). Herein, w [...]
25 June 2024 |
Chemistry; Radiation and Cellular Oncology |
Article |
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6.
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Recent studies have linked elevated tumor aneuploidy to anti-tumor immune suppression and adverse survival following immunotherapy. Herein, we provide supportive evidence [...]
21 August 2024 |
Radiation and Cellular Oncology |
Article |
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7.
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The combination of cuproptosis and immune checkpoint inhibition has shown promise in treating malignant tumors. However, it remains a challenge to deliver copper ions and [...]
16 July 2024 |
Chemistry; Radiation and Cellular Oncology |
Article |
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8.
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A method of radiating a plurality of masses in a patient is provided, including receiving a three-dimensional model of the patient, the model including respective locatio [...]
21 May 2024 |
Microbiology; Radiation and Cellular Oncology |
Patent |
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9.
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The low success rate of cancer nanomedicines has raised debate on the role of the enhanced permeability and retention (EPR) effect on tumor deposition of nanotherapeutics [...]
17 July 2024 |
Chemistry; Radiation and Cellular Oncology |
Article |
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10.
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Radiotherapy is a cancer treatment that uses high-energy X-rays to kill cancer cells. A major challenge in treating cancer is the heterogeneity of the disease. Preclinica [...]
09 May 2024 |
Biological Sciences; Mathematics; Radiation and Cellular Oncology |
Thesis |
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11.
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The proto-oncogene MYC encodes a nuclear transcription factor that has an important role in a variety of cellular processes, such as cell cycle progression, proliferation [...]
23 May 2024 |
Ben May Department for Cancer Research; Medicine; Pathology; Radiation and Cellular Oncology; Surgery |
Article |
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12.
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The use of oxygen by cells is an essential aspect of cell metabolism and a reliable indicator of viable and functional cells. Viable and functional cells are essential fo [...]
01 April 2024 |
Radiation and Cellular Oncology |
Article |
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13.
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Chemoradiotherapy combines radiotherapy with concurrent chemotherapy to potentiate antitumor activity but exacerbates toxicities and causes debilitating side effects in c [...]
21 February 2024 |
Chemistry; Radiation and Cellular Oncology |
Article |
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14.
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Importance: Clinical trials for metastatic malignant neoplasms are increasingly being extended to patients with brain metastases. Despite the preeminence of progressio [...]
26 April 2023 |
Radiation and Cellular Oncology |
Article |
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15.
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Importance: Clinical practice regarding posttreatment radiologic surveillance for patients with oropharyngeal carcinoma (OPC) is neither adapted to individual patient [...]
13 April 2022 |
Medicine; Radiation and Cellular Oncology; Radiology; Surgery |
Article |
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16.
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Importance: Postoperative chemoradiation is the standard of care for cancers with positive margins or extracapsular extension, but the benefit of chemotherapy is uncle [...]
19 November 2020 |
Medicine; Radiation and Cellular Oncology |
Article |
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17.
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Cell encapsulation represents a promising therapeutic strategy for many hormone-deficient diseases such as type 1 diabetes (T1D). However, adequate oxygenation of the enc [...]
14 May 2021 |
Radiation and Cellular Oncology |
Article |
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18.
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Cancer vaccines have been actively pursued to bolster antitumor immunity. Here, we designed nanoscale metal-organic frameworks (nMOFs) as locally activable immunotherapeu [...]
02 October 2020 |
Chemistry; Radiation and Cellular Oncology |
Article |
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19.
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RAD51 recombinase polymerizes at the site of double-strand breaks (DSBs) where it performs DSB repair. The loss of RAD51 causes extensive chromosomal breaks, leading t [...]
14 July 2011 |
Radiation and Cellular Oncology |
Article |
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20.
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These studies define a new mechanism-based approach to radiosensitize tumor cure by single dose radiotherapy (SDRT). Published evidence indicates that SDRT induces acu [...]
02 August 2013 |
Radiation and Cellular Oncology |
Article |
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21.
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Previous reports have implicated an induction of genes in IFN/STAT1 (Interferon/STAT1) signaling in radiation resistant and prosurvival tumor phenotypes in a number of [...]
05 January 2012 |
Radiation and Cellular Oncology |
Article |
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22.
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During meiosis, repair of programmed DNA double-strand breaks (DSBs) by recombination promotes pairing of homologous chromosomes and their connection by crossovers. Tw [...]
19 December 2013 |
Human Genetics; Molecular Genetics and Cell Biology; Radiation and Cellular Oncology |
Article |
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23.
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Background: Traditionally IFN/STAT1 signaling is connected with an anti-viral response and pro-apoptotic tumor-suppressor functions. Emerging functions of a constituti [...]
08 June 2009 |
Radiation and Cellular Oncology; Surgery |
Article |
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24.
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Background: Vascular endothelial cells contribute to the pathogenesis of numerous human diseases by actively regulating the stromal inflammatory response; however, lit [...]
04 October 2012 |
Radiation and Cellular Oncology |
Article |
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25.
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Rationale: Strategies to stage and treat cancer rely on a presumption of either localized or widespread metastatic disease. An intermediate state of metastasis termed [...]
10 December 2012 |
Medicine; Radiation and Cellular Oncology; Surgery |
Article |
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