Neurobiology

The stability of ecological systems has been a long-standing focus of ecology. Recently, tools from random matrix theory have identified the main drivers of stability in [...]

In natural visually guided behavior, observers must separate relevant information from a barrage of irrelevant information. Many studies have investigated the neural unde [...]

Lipid membranes are key to the nanoscale compartmentalization of biological systems, but fluorescent visualization of them in intact tissues, with nanoscale precision, is [...]

Prehensile arms are among the most remarkable features of the octopus, but little is known about the neural circuitry controlling arm movements. Here, we report on the ce [...]

Purpose: Many reproductive age women, cared for routinely by primary care providers (PCPs), would benefit from interconception care, yet a minority of primary care vis [...]

Purpose: A glioblastoma (GBM) is a primary brain tumor with significant unmet therapeutic needs. Immune checkpoint inhibitors (ICIs) have marked therapeutic benefits in m [...]

Mechanisms of computation in sensorimotor cortex must be flexible and robust to support skilled motor behavior. Patterns of neuronal coactivity emerge as a result of comp [...]

In amniotes, head motions and tilt are detected by two types of vestibular hair cells (HCs) with strikingly different morphology and physiology. Mature type I HCs express [...]

This dataset includes data from isolated mouse neurons via whole-cell patch clamp electrophysiology. We present data of currents isolated with pharmacological assays. We [...]

Vestibular afferent neurons occur as two populations with differences in spike timing regularity that are independent of rate. The more excitable regular afferents have l [...]

Otolith organs in the inner ear and neuromasts in the fish lateral-line harbor two populations of hair cells oriented to detect stimuli in opposing directions. The underl [...]

Opioid-induced respiratory depression (ORID) is the hallmark of opioid overdose and a major risk factor for death due to fentanyl. While repeat opioid use (ROU) elevates [...]

Canonically, each Purkinje cell (PC) in the adult cerebellum receives only one climbing fiber (CF) from the inferior olive. Underlying current theories of cerebellar func [...]

Neuromodulatory inputs to the hippocampus play pivotal roles in modulating synaptic plasticity, shaping neuronal activity, and influencing learning and memory. Recently, [...]

A core problem in systems and circuits neuroscience is deciphering the origin of shared dynamics in neuronal activity: Do they emerge through local network interactions, [...]

Electron imaging of biological samples stained with heavy metals has enabled visualization of subcellular structures critical in chemical-, structural-, and neuro-biology [...]

A key to motor control is the motor thalamus, where several inputs converge. One excitatory input originates from layer 5 of primary motor cortex (M1_L5), while [...]

The basal ganglia play pivotal roles in motor control and cognitive functioning. These nuclei are embedded in an anatomical loop: cortex to basal ganglia to thalamus back [...]

Changes in synaptic strength across timescales are integral to algorithmic operations of neural circuits. However, pinpointing synaptic loci that undergo plasticity in in [...]

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Background: Brain recovery mechanisms after injuries like aneurysmal subarachnoid hemorrhage (aSAH), ischemic stroke (IS), and traumatic brain injury (TBI) involve bra [...]

Synaptic connectivity defines groups of neurons that engage in correlated activity during specific functional tasks. These co-active groups of neurons form ensembles, the [...]

Perception is largely supported by cortical processing that involves communication among multiple areas, typically starting with primary sensory cortex and then involving [...]

Infantile neuronal ceroid lipofuscinosis (CLN1 Batten Disease) is a devastating pediatric lysosomal storage disease caused by pathogenic variants in the CLN1 gen [...]

As the primary inhibitory neurotransmitter in the central nervous system, γ-aminobutyric acid (GABA) plays a critical role in controlling neural activity. Dysregulation [...]