Rationale: Strategies to stage and treat cancer rely on a presumption of either localized or widespread metastatic disease. An intermediate state of metastasis termed oligometastasis(es) characterized by limited progression has been proposed. Oligometastases are amenable to treatment by surgical resection or radiotherapy.
Methods: We analyzed microRNA expression patterns from lung metastasis samples of patients with ≤5 initial metastases resected with curative intent.
Results: Patients were stratified into subgroups based on their rate of metastatic progression. We prioritized microRNAs between patients with the highest and lowest rates of recurrence. We designated these as high rate of progression (HRP) and low rate of progression (LRP); the latter group included patients with no recurrences. The prioritized microRNAs distinguished HRP from LRP and were associated with rate of metastatic progression and survival in an independent validation dataset.
Conclusion: Oligo- and poly- metastasis are distinct entities at the clinical and molecular level.
Details
Title
Oligo- and Polymetastatic Progression in Lung Metastasis(es) Patients Is Associated with Specific MicroRNAs
Author
Lussier, Yves A. : University of Chicago Khodarev, Nikolai N. : University of Chicago Regan, Kelly : University of Illinois at Chicago Corbin, Kimberly : University of Chicago Li, Haiquan : University of Illinois at Chicago Ganai, Sabha : University of Chicago Khan, Sajid A. : University of Chicago Gnerlich, Jennifer : University of Chicago Darga, Thomas E. : University of Chicago Fan, Hanli : University of Illinois at Chicago Karpenko, Oleksiy : University of Illinois at Chicago Paty, Philip B. : Memorial Sloan-Kettering Cancer Center Posner, Mitchell C. : University of Chicago Chmura, Steven J. : University of Chicago Hellman, Samuel : University of Chicago Ferguson, Mark K. : University of Chicago Weichselbaum, Ralph R. : University of Chicago
Funding Information
Ludwig Center for Metastasis, Research Grant Center for Radiation Therapy Chicago Tumor Institute Ludwig Foundation for Cancer Research Mr. and Mrs. Vincent Foglia Foglia Foundation Lung Cancer Research Foundation Cancer Research Foundation National Institutes of Health, K22 LM008308-04 National Institutes of Health, 5UL1RR024999- 04 National Institutes of Health, 5P30CA014599-35 University of Illinois, Cancer Center University of Illinois, Center for Clinical and Translational Science, UL1RR029879
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