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No abstract
18 February 2022 |
Ecology and Evolution |
Article |
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Biological organisms experience constantly changing environments, from sudden changes in physiology brought about by feeding, to the regular rising and setting of the Sun [...]
17 May 2021 |
Molecular Genetics and Cell Biology[...] |
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Most eukaryotic genes encode polypeptides that are either obligate members of hetero-stoichiometric complexes or clients of organelle-targeting pathways. Proteins in thes [...]
15 November 2024 |
Molecular Genetics and Cell Biology |
Article |
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Proteins are molecular machines and to understand how they work, we need to understand how they move. New pump-probe time-resolved X-ray diffraction methods open up ways [...]
15 April 2024 |
Biochemistry and Molecular Biology[...] |
Article |
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Several physical mechanisms have been proposed to explain allostery in proteins. They differ by the number of internal states that they assume a protein to occupy, leavin [...]
09 November 2023 |
Biochemistry and Molecular Biology[...] |
Article |
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Epistatic interactions between mutations add substantial complexity to adaptive landscapes and are often thought of as detrimental to our ability to predict evolution. [...]
03 April 2023 |
Ecology and Evolution |
Article |
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The metabolic activity of microbial communities is central to their role in biogeochemical cycles, human health, and biotechnology. Despite the abundance of sequencing da [...]
19 December 2023 |
Biophysical Sciences[...] |
Article |
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To achieve maximal growth, cells must manage a massive economy of ribosomal proteins (r-proteins) and RNAs (rRNAs) to produce thousands of ribosomes every minute. Althoug [...]
07 March 2019 |
Molecular Genetics and Cell Biology |
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Protein function arises from a poorly understood pattern of energetic interactions between amino acid residues. Sequence-based strategies for deducing this pattern have b [...]
19 July 2018 |
Biochemistry and Molecular Biology |
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Cellular behaviors emerge from layers of molecular interactions: proteins interact to form complexes, pathways, and phenotypes. We show that hierarchical networks of prot [...]
17 August 2022 |
Pathology |
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The heat shock response (HSR) controls expression of molecular chaperones to maintain protein homeostasis. Previously, we proposed a feedback loop model of the HSR in whi [...]
09 May 2023 |
Genetics, Genomics, and Systems Biology[...] |
Article |
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12.
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The ribosome translates the genetic code into proteins in all domains of life. Its size and complexity demand long-range interactions that regulate ribosome function. The [...]
03 August 2020 |
Biochemistry and Molecular Biology |
Article |
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13.
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Cycles of nutrients (N, P, etc.) and resources (C) are a defining emergent feature of ecosystems. Cycling plays a critical role in determining ecosystem structure at all [...]
05 November 2021 |
Ecology and Evolution |
Article |
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14.
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Microbial community assembly is a complex dynamical process that determines community structure and function. The interdependence of inter-species interactions and nutrie [...]
26 May 2023 |
Ecology and Evolution |
Article |
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