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Somatic structural variations (SVs) in cancer can shuffle DNA content in the genome, relocate regulatory elements, and alter genome organization. Enhancer hijacking occur [...]
25 July 2024 |
Ben May Department for Cancer Research; Human Genetics |
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The tumor microenvironment is a determinant of cancer progression and therapeutic efficacy, with nutrient availability playing an important role. Although it is establish [...]
24 May 2024 |
Ben May Department for Cancer Research; Surgery |
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The proto-oncogene MYC encodes a nuclear transcription factor that has an important role in a variety of cellular processes, such as cell cycle progression, proliferation [...]
23 May 2024 |
Ben May Department for Cancer Research; Medicine; Pathology; Radiation and Cellular Oncology; Surgery |
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The functional role of progesterone receptor (PR) and its impact on estrogen signaling in breast cancer remain controversial. In primary ER + (estrogen receptor [...]
24 June 2016 |
Ben May Department for Cancer Research |
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Metabolism-mediated epigenetic changes represent an adapted mechanism for cellular signaling, in which lysine acetylation and methylation have been the historical focus o [...]
24 February 2021 |
Ben May Department for Cancer Research |
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Lysine L-lactylation [K(L-la)] is a newly discovered histone mark stimulated under conditions of high glycolysis, such as the Warburg effect. K(L-la) is associated with f [...]
19 January 2022 |
Ben May Department for Cancer Research |
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Although a clinical breakthrough for cancer treatment, it remains that a minority of patients respond to checkpoint inhibitor (CPI) immunotherapy. The composition of tumo [...]
11 December 2019 |
Ben May Department for Cancer Research; Immunology |
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Hepatic steatosis is a major etiological factor in hepatocellular carcinoma (HCC), but factors causing lipid accumulation leading to HCC are not understood. We identify B [...]
12 October 2022 |
Ben May Department for Cancer Research; Cancer Biology; Molecular Metabolism and Nutrition |
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The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and ongoing coronavirus disease 2019 (COVID-19) pandemic underscores the need for new treatment [...]
20 January 2022 |
Ben May Department for Cancer Research; Chemistry; Microbiology; Pathology; Surgery |
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10.
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Fusion genes represent a class of attractive therapeutic targets. Thousands of fusion genes have been identified in patients with cancer, but the functional consequences [...]
09 February 2022 |
Ben May Department for Cancer Research; Human Genetics |
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11.
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Oxysterols are oxidation products of cholesterol. Cholestane-3β, 5α, 6β-triol (abbreviated as triol) is one of the most abundant and active oxysterols. Here, we report [...]
13 June 2013 |
Accounting; Ben May Department for Cancer Research; Genetics, Genomics, and Systems Biology |
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12.
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Cancer and healthy cells have distinct distributions of molecular properties and thus respond differently to drugs. Cancer drugs ideally kill cancer cells while limiti [...]
23 September 2014 |
Ben May Department for Cancer Research; Physics |
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13.
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Cervical cancer is one of the most common cancers in women worldwide, being high-risk group the HPV infected, the leading etiological factor. The raf kinase inhibitory [...]
19 March 2013 |
Ben May Department for Cancer Research |
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14.
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Guanylyl cyclases (GCs) regulate many physiological processes by catalyzing the synthesis of the second messenger cGMP. The GC family consists of seven particulate GCs [...]
29 July 2013 |
Ben May Department for Cancer Research |
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15.
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Background: Recent studies show that mutations in Leucine Rich Repeat Kinase 2 (LRRK2) are the cause of the most common in [...]
01 March 2011 |
Ben May Department for Cancer Research |
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16.
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There is a growing body of evidence that epigenetic alterations are involved in the pathological mechanisms of many chronic disorders linked to fetal programming. Angi [...]
29 August 2014 |
Ben May Department for Cancer Research |
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Background: Insulin is a vital peptide hormone that is a central regulator of glucose homeostasis, and impairments in insulin signaling cause diabetes mellitus. In pri [...]
07 May 2010 |
Ben May Department for Cancer Research |
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18.
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First-generation interaction maps of Src homology 2 (SH2) domains with receptor tyrosine kinase (RTK) phosphosites have previously been generated using protein microar [...]
04 September 2012 |
Ben May Department for Cancer Research; Cancer Biology; Genetics, Genomics, and Systems Biology |
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19.
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Although triple negative breast cancers (TNBC) are the most aggressive subtype of breast cancer, they currently lack targeted therapies. Because this classification st [...]
11 December 2013 |
Ben May Department for Cancer Research; Ecology and Evolution; Molecular Genetics and Cell Biology; Statistics |
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20.
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Angiogenesis inhibition is an important therapeutic strategy for advanced stage prostate cancer. Previous work from our laboratory showed that sustained stimulation of [...]
15 November 2012 |
Ben May Department for Cancer Research |
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21.
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Recent proteomics studies suggest high abundance and a much wider role for lysine acetylation (K-Ac) in cellular functions. Nevertheless, cross influence between K-Ac [...]
02 December 2011 |
Ben May Department for Cancer Research; Pediatrics |
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22.
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Background: Raf kinase inhibitory protein (RKIP), also known as phoshaptidylethanolamine binding protein (PEBP), has been shown to inhibit Raf and thereby negatively r [...]
05 May 2010 |
Ben May Department for Cancer Research; Biochemistry and Molecular Biology; Neurobiology; Pharmacological and Physiological Sciences |
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23.
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Background: Raf Kinase Inhibitory Protein (RKIP, also PEBP1), a member of the Phosphatidylethanolamine Binding Protein family, negatively regulates growth factor signa [...]
24 June 2009 |
Ben May Department for Cancer Research; Biochemistry and Molecular Biology; Neurobiology; Pharmacological and Physiological Sciences |
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24.
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Inactivation of the Rb tumor suppressor can lead to increased cell proliferation or cell death depending on specific cellular context. Therefore, identification of the [...]
08 May 2014 |
Ben May Department for Cancer Research |
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25.
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The phosphoinositol-3 kinase (PI3K) pathway is highly dysregulated in squamous cell carcinoma of the head and neck (SCCHN). While inhibitors of the PI3K/AKT pathway ar [...]
05 March 2014 |
Ben May Department for Cancer Research; Cancer Biology; Medicine |
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