Provided are methods of activating an NKT cell which include a step of contacting the NKT cell with a sufficient amount of isoglobotrihexosylceramide (iGb3) to induce secretion of a cytokine from the NKT cell, stimulate proliferation of the NKT cell or upregulate expression of a cell surface marker on the NKT cell. Methods of activating an NKT cell population in a subject are also provided.
Details
Title
METHODS OF ACTIVATING NKT CELLS
Inventors
Bendelac, Albert : University of Chicago Zhou, Dapeng : University of Chicago Teyton, Luc : Scripps Research Institute Savage, Paul : Brigham Young University
Applicants
University of Chicago Brigham Young University Scripps Research Institute