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1.
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Tissue lymphatics are crucial for fluid homeostasis and immunosurveillance. We asked whether the lymphatics are adapted to the organ in which they reside, such as along t [...]
2024-08 |
Immunology |
Dissertation |
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2.
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The mucosal barrier of the gastrointestinal tract is essential for maintaining tolerance to the commensal microbiota and protecting the host from pathogenic infections. A [...]
2024-08 |
Immunology |
Dissertation |
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3.
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The innate immune system is the first line of defense against pathogens and immunological threats. By engaging a large cassette of pattern recognition receptors (PRRs) t [...]
2024-08 |
Immunology |
Dissertation |
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4.
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Classical NK cells are the prototypical type 1 innate lymphocytes mounting cytolytic and IFNγ responses to intracellular pathogens and tumors. A similar but distinc [...]
2024-08 |
Immunology |
Dissertation |
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5.
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Checkpoint blockade immunotherapy (CBI) is a cornerstone of modern cancer treatment, but efficacy is not universal, partly due to a wide variation in baseline immune cell [...]
2024-06 |
Immunology |
Dissertation |
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6.
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Allergic asthma is an increasing burden in industrialized countries, where treatments are limited to treating symptoms rather than root causes. In recent years, the use o [...]
2024-06 |
Immunology |
Dissertation |
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7.
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This study aimed to elucidate the complex interplay between microbiota diversity, microbial-derived signals, and alloimmune responses in the context of allograft rejectio [...]
2024-06 |
Immunology |
Dissertation |
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8.
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Host-microbiota-pathogen interactions play a key role in determining survival from lethal bacterial infection leading to sepsis. Here we demonstrate that western diet, h [...]
2024-06 |
Immunology |
Dissertation |
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9.
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T cell Acute Lymphoblastic Leukemia (T-ALL) is a highly heterogeneous hematological malignancy resulting from the transformation of immature thymocytes during their devel [...]
2024-06 |
Immunology |
Dissertation |
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10.
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Antituberculosis drugs, mostly developed over 60 years ago, combined with a poorly effective vaccine, have failed to eradicate tuberculosis. More worryingly, multiresista [...]
29 April 2024 |
Genetics, Genomics, and Systems Biology; Immunology; Medicine |
Article |
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11.
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Commensal microbes have the capacity to affect development and severity of autoimmune diseases. Germ-free (GF) animals have proven to be a fine tool to obtain definitive [...]
08 May 2024 |
Cancer Biology; Immunology; Microbiology; Pathology |
Article |
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12.
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RNA velocity estimation is a potentially powerful tool to reveal the directionality of transcriptional changes in single-cell RNA-sequencing data, but it lacks accuracy, [...]
26 April 2024 |
Chemistry; Immunology; Medicine |
Article |
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13.
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Bacillus Calmette–Guérin (BCG) vaccination induces memory characteristics in innate immune cells and their progenitors, a process called trained immunity mediated by e [...]
11 March 2024 |
Immunology; Medicine |
Article |
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14.
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Humans exhibit considerable variability in their immune responses to the same immune challenges. Such variation is widespread and affects individual and population-level [...]
05 April 2024 |
Genetics, Genomics, and Systems Biology; Human Genetics; Immunology; Medicine |
Article |
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15.
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Previously, we showed that a massively parallel reporter assay, mSTARR-seq, could be used to simultaneously test for both enhancer-like activity and DNA methylation-depen [...]
26 February 2024 |
Human Genetics; Immunology; Medicine |
Article |
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16.
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The vast diversity of mammalian adaptive antigen receptors allows for robust and efficient immune responses against a wide number of pathogens. The antigen receptor reper [...]
04 March 2024 |
Genetics, Genomics, and Systems Biology; Immunology; Microbiology |
Article |
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17.
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Demand-adjusted and cell type specific rates of protein synthesis represent an important safeguard for fate and function of long-term hematopoietic stem cells. Here, we i [...]
29 February 2024 |
Immunology |
Article |
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18.
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The revolutionizing efficacy of recombinant human bone morphogenetic protein (rhBMP-2) for clinical spinal fusion is hindered by safety issues associated with the high do [...]
11 June 2021 |
Cancer Biology; Immunology; Radiology |
Article |
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19.
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Enhancing the therapeutic efficacy of drugs for inflammatory diseases is of high demand. One possible approach is targeting drugs to the extracellular matrix of the infla [...]
06 November 2019 |
Immunology |
Article |
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20.
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Although a clinical breakthrough for cancer treatment, it remains that a minority of patients respond to checkpoint inhibitor (CPI) immunotherapy. The composition of tumo [...]
11 December 2019 |
Ben May Department for Cancer Research; Immunology |
Article |
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21.
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Background: Primary Toxoplasma gondii infection during pregnancy can be transmitted to the fetus. At birth, infected infants may have intracranial calcification, hydro [...]
04 June 2008 |
Immunology; Medicine; Ophthalmology and Visual Science; Pediatrics |
Article |
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22.
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Embodiments concern methods and composition related to anergic T-cells in patients, such as cancer patients.
13 May 2021 |
Immunology; Medicine |
Patent |
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23.
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Molecular pathways regulating rapid proliferation and persistence are fundamental for pathogens but are not elucidated fully in Toxoplasma gondii. Promoters o [...]
22 November 2010 |
Immunology; Pathology; Pediatrics; Surgery |
Article |
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24.
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Background: Id3 is a dominant antagonist of E protein transcription factor activity that is induced by signals emanating from the αβ and γδ T cell receptor (TCR). [...]
19 February 2010 |
Biochemistry and Molecular Biology; Immunology; Pathology |
Article |
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25.
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Candida albicans is an opportunistic pathogen that proliferates in the intestinal tract of critically ill patients where it continues to be a major cause of i [...]
13 January 2012 |
Immunology; Microbiology; Surgery |
Article |
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