A common side effect of antibiotic treatment is the depletion of the patient’s endogenous gut microbiota, which provides critical protection from antibiotic-resistant pat [...]

In the current thesis work, we set out to understand how the host microbiota, intestinal epithelial cells, and immune system work together to promote barrier integrity an [...]

Major histocompatibility complex-related protein 1 (MR1) is a highly conserved non-polymorphic antigen presenting protein that is well known for the presentation of micro [...]

Microbial impact on tumorigenesis of heritable cancers proximal to the gut is well-documented. Whether the microbiota influences cancers arising from inborn mutations at [...]

The appendix is a secondary lymphoid organ that sits at the junction between the small and large intestine. Housing both dense lymphoid tissue and its own microbiome, [...]

Vertebrates differ over 100,000-fold in responses to pro-inflammatory agonists such as bacterial lipopolysaccharide (LPS), complicating use of animal models to study huma [...]

Volume-regulated anion channels (VRACs) are heteromeric complexes formed by proteins of the leucine-rich repeat-containing 8 (LRRC8) family. LRRC8A (also known as SWELL1) [...]

Provided herein are anti-neuraminidase agents useful for neutralization of influenza virus infection, and methods of use and manufacture thereof. In particular, compositi [...]

Provided herein are anti-neuraminidase agents useful for neutralization of influenza virus infection, and methods of use and manufacture thereof. In particular, compositi [...]

Provided herein are anti-neuraminidase agents useful for neutralization of influenza virus infection, and methods of use and manufacture thereof. In particular, compositi [...]

Celiac disease (CeD) is a complex intestinal inflammatory disorder that is triggered by dietary gluten and develops in genetically susceptible individuals expressing [...]

The determination of the cancer prognosis is paramount for patients and medical personnel so that they can devise treatment strategies. Transcriptional-based signatures a [...]

Immune stimulating agents like Toll-like receptor 7 (TLR7) agonists induce potent antitumor immunity but are limited in their therapeutic window due to off-target immune [...]

Background: Toxoplasmosis is potentially avoidable, treatable, and curable by simple and direct preventive measures. Knowledge, attitudes, and practices (KAP) assessme [...]

Tissue lymphatics are crucial for fluid homeostasis and immunosurveillance. We asked whether the lymphatics are adapted to the organ in which they reside, such as along t [...]

The mucosal barrier of the gastrointestinal tract is essential for maintaining tolerance to the commensal microbiota and protecting the host from pathogenic infections. A [...]

The innate immune system is the first line of defense against pathogens and immunological threats. By engaging a large cassette of pattern recognition receptors (PRRs) t [...]

Classical NK cells are the prototypical type 1 innate lymphocytes mounting cytolytic and IFNγ responses to intracellular pathogens and tumors. A similar but distinct popu [...]

Checkpoint blockade immunotherapy (CBI) is a cornerstone of modern cancer treatment, but efficacy is not universal, partly due to a wide variation in baseline immune cell [...]

Allergic asthma is an increasing burden in industrialized countries, where treatments are limited to treating symptoms rather than root causes. In recent years, the use o [...]

This study aimed to elucidate the complex interplay between microbiota diversity, microbial-derived signals, and alloimmune responses in the context of allograft rejectio [...]

Host-microbiota-pathogen interactions play a key role in determining survival from lethal bacterial infection leading to sepsis. Here we demonstrate that western diet, h [...]

T cell Acute Lymphoblastic Leukemia (T-ALL) is a highly heterogeneous hematological malignancy resulting from the transformation of immature thymocytes during their devel [...]

Antituberculosis drugs, mostly developed over 60 years ago, combined with a poorly effective vaccine, have failed to eradicate tuberculosis. More worryingly, multiresista [...]

Commensal microbes have the capacity to affect development and severity of autoimmune diseases. Germ-free (GF) animals have proven to be a fine tool to obtain definitive [...]