|
1.
|
RNA molecules often play critical roles in assisting the formation of membraneless organelles in eukaryotic cells. Yet, little is known about the organization of RNAs wit [...]
27 March 2024 |
Biochemistry and Molecular Biology; Biological Sciences; Biophysical Sciences; Physics |
Article |
|
|
2.
|
Cells must sense and respond to sudden maladaptive environmental changes—stresses—to survive and thrive. Across eukaryotes, stresses such as heat shock trigger conser [...]
11 April 2024 |
Biochemistry and Molecular Biology; Biophysical Sciences; Genetics, Genomics, and Systems Biology; Medicine |
Article |
|
|
3.
|
Despite the generally accepted role of the hydrophobic effect as the driving force for folding, many intrinsically disordered proteins (IDPs), including those with hydrop [...]
12 April 2024 |
Biochemistry and Molecular Biology; Biophysical Sciences |
Article |
|
|
4.
|
Several physical mechanisms have been proposed to explain allostery in proteins. They differ by the number of internal states that they assume a protein to occupy, leavin [...]
09 November 2023 |
Biochemistry and Molecular Biology; Biophysical Sciences |
Article |
|
|
5.
|
Bimolecular condensation plays a role in many cellular processes. Despite considerable progress, a residue-level description of condensates has been lacking as obtaining [...]
21 March 2024 |
Biochemistry and Molecular Biology; Biophysical Sciences |
Article |
|
|
6.
|
In active materials, uncoordinated internal stresses lead to emergent long-range flows. An understanding of how the behavior of active materials depends on mesoscopic (hy [...]
02 February 2024 |
Biophysical Sciences; Chemistry; Physics |
Article |
|
|
7.
|
Plasmids are extrachromosomal genetic elements that often encode fitness-enhancing features. However, many bacteria carry “cryptic” plasmids that do not confer clear [...]
29 February 2024 |
Biochemistry and Molecular Biology; Biophysical Sciences; Medicine; Microbiology |
Article |
|
|
8.
|
Dendritic mechanisms driving input-output transformation in starburst amacrine cells (SACs) are not fully understood. Here, we combine two-photon subcellular voltage and [...]
28 February 2024 |
Biophysical Sciences; Computational Neuroscience; Neurobiology |
Article |
|
|
9.
|
To date, effective therapeutic treatments that confer strong attenuation against coronaviruses (CoVs) remain elusive. Among potential drug targets, the helicase of CoVs i [...]
07 January 2022 |
Biophysical Sciences |
Article |
|
|
10.
|
Little is understood about the embryonic development of sociality. We screened 1120 known drugs and found that embryonic inhibition of topoisomerase IIα (Top2a) resulted [...]
23 November 2022 |
Biophysical Sciences |
Article |
|
|
11.
|
<p>Sediment microbial communities are responsible for a majority of the metabolic activity in river and stream ecosystems. Understanding the dynamics in community s [...]
19 May 2014 |
Biophysical Sciences; Ecology and Evolution; Geophysical Sciences |
Article |
|
|
12.
|
<p>Recent advances in DNA sequencing technologies have allowed scientists to probe increasingly complex biological systems, including the diversity of bacteria in t [...]
31 July 2013 |
Biophysical Sciences; Ecology and Evolution; Evolutionary Biology |
Article |
|
|
13.
|
<p>Understanding microbial partnerships with the medicinally and economically important crop <em>Cannabis</em> has the potential to affect agricultural [...]
16 June 2014 |
Biophysical Sciences; Ecology and Evolution; Evolutionary Biology |
Article |
|
|
14.
|
<p>We have experimentally and computationally defined a set of genes that form a conserved metabolic module in the α-proteobacterium <em>Caulobacter crescent [...]
19 December 2008 |
Biochemistry and Molecular Biology; Biophysical Sciences; Microbiology |
Article |
|
|
15.
|
<p>Robust methods for identifying patterns of expression in genome-wide data are important for generating hypotheses regarding gene function. To this end, several a [...]
20 March 2015 |
Biophysical Sciences; Chemistry |
Article |
|
|
16.
|
The metabolic activity of microbial communities is central to their role in biogeochemical cycles, human health, and biotechnology. Despite the abundance of sequencing da [...]
19 December 2023 |
Biophysical Sciences; Ecology and Evolution; Physics |
Article |
|
|
17.
|
Traditional cultivation approaches in microbiology are labor-intensive, low-throughput, and yield biased sampling of environmental microbes due to ecological and evolutio [...]
17 June 2020 |
Biophysical Sciences; Medicine |
Article |
|
|
18.
|
Spatially distributed excitation and inhibition collectively shape a visual neuron’s receptive field (RF) properties. In the direction-selective circuit of the mammalia [...]
07 June 2021 |
Biophysical Sciences; Neurobiology; Organismal Biology and Anatomy |
Article |
|
|
19.
|
Members of the SAR11 order Pelagibacterales dominate the surface oceans. Their extensive diversity challenges emerging operational boundaries defined for microbial ’spe [...]
03 September 2019 |
Biophysical Sciences; Medicine |
Article |
|
|
20.
|
Heat shock induces a conserved transcriptional program regulated by heat shock factor 1 (Hsf1) in eukaryotic cells. Activation of this heat shock response is triggered by [...]
07 August 2020 |
Biochemistry and Molecular Biology; Biophysical Sciences; Chemistry |
Article |
|
|
21.
|
Circadian rhythms are biological oscillations that schedule daily changes in physiology. Outside the laboratory, circadian clocks do not generally free-run but are driven [...]
07 July 2017 |
Biochemistry and Molecular Biology; Biophysical Sciences; Chemistry; Ecology and Evolution; Molecular Genetics and Cell Biology; Physics |
Article |
|
|
22.
|
Antibodies are critical components of adaptive immunity, binding with high affinity to pathogenic epitopes. Antibodies undergo rigorous selection to achieve this high aff [...]
10 November 2020 |
Biochemistry and Molecular Biology; Biophysical Sciences; Immunology; Medicine; Pathology |
Article |
|
|
23.
|
Seagrasses are important primary producers in oceans worldwide. They live in shallow coastal waters that are experiencing carbon dioxide enrichment and ocean acidificatio [...]
15 November 2023 |
Biophysical Sciences; Ecology and Evolution |
Article |
|
|
24.
|
Vascular disease is a leading cause of morbidity and mortality in the United States and globally. Pathological vascular remodeling, such as atherosclerosis and stenosis, [...]
08 December 2021 |
Biophysical Sciences; Medicine |
Article |
|
|
25.
|
Comprehensive sampling of natural genetic diversity with metagenomics enables highly resolved insights into the interplay between ecology and evolution. However, resolvin [...]
22 February 2023 |
Biochemistry and Molecular Biology; Biophysical Sciences; Medicine |
Article |
|
