Self-assembled thin films respond to external loads via surface instabilities that are critical to their functionality in both biology and technology. Lipid monolayers [...]

Targeting ribosome biogenesis and protein translation has emerged as a promising avenue for cancer therapy. The fat mass and obesity-associated protein (FTO), an RNA N 15 August 2025 | Biochemistry and Molecular Biology[...] | Article |

Cellular plasticity is a principal feature of vertebrate adaptation, tissue repair and tumorigenesis. However, the mechanisms that regulate the stability of somatic cell [...]

Detecting and quantifying the strength of selection is a major objective in population genetics. Since selection acts over multiple generations, many approaches have been [...]

Proteins are not static structures; they are dynamic machines whose motions underpin nearly all aspects of biological function. While structure prediction tools such as A [...]

Multicellular organisms rely on their constituent cells to adopt distinct fates and maintain stable identities and functions. At the same time, cells retain a degree of f [...]

We are witnessing a significant increase in complex T cell-mediated immune disorders, such as food allergies and autoimmune diseases, which are driven by diverse inflamma [...]

Allostery is a fundamental property of proteins, describing the functional coupling between distantly separated sites within the molecule. In different manifestations, th [...]

A wide variety of human diseases are associated with loss of microbial diversity in the human gut, inspiring a great interest in the diagnostic or therapeutic potential o [...]

Global deserts occupy one-third of the Earth’s surface and contribute significantly to organic carbon storage, a process at risk in dryland ecosystems that are highly [...]

The oscillator of the cyanobacterial circadian clock relies on the ability of the KaiB protein to switch reversibly between a stable ground-state fold (gsKaiB) and an uns [...]

Chemical waves represent one of the fundamental behaviors that emerge in nonlinear, out-of-equilibrium chemical systems. They also play a central role in regulating behav [...]

External stressors modulate the oligomerization state of photosystem I (PSI) in cyanobacteria. The number of red chlorophylls (Chls), pigments lower in energy than the P< [...]

Active biological molecules present a powerful, yet largely untapped, opportunity to impart autonomous regulation of materials. Because these systems can function robustl [...]

Phytosulfokine (PSK) is a plant growth-promoting peptide hormone that is perceived by its cell surface receptors PSKR1 and PSKR2 in Arabidopsis. Plants lacking the PSK re [...]

Abstract. The impact of ocean acidification and carbonation on microbial community structure was assessed during a large-scale in situ costal pelagic mesocosm study, incl [...]

The multiscale organizational structure of chromatin in eukaryotic cells is instrumental to DNA transcription, replication, and repair. At mesoscopic length scales, nucle [...]

Scanning transmission electron microscopy tomography with ChromEM staining (ChromSTEM), has allowed for the three-dimensional study of genome organization. By leveraging [...]

The denaturant dependence of hydrogen–deuterium exchange (HDX) is a powerful measurement to identify the breaking of individual H-bonds and map the free energy surface (F [...]

Structure-based drug design, which relies on precise understanding of the target protein and its interaction with the drug candidate, is dramatically expedited by advance [...]

The use of trivalent erbium (Er³⁺), typically embedded as an atomic defect in the solid-state, has widespread adoption as a dopant in telecommunication devices [...]

Structured Illumination Microscopy (SIM) is gaining increasing attention in the field of bioimaging for its capability to strike a balance between high spatial resolution [...]

In coastal marine ecosystems, kelp forests serve as a vital habitat for numerous species and significantly influence local nutrient cycles. Bull kelp, or Nereocystis luet [...]

This work explores how endothelial cells respond to and regulate immune responses, specificallyfocusing on lymphatic endothelial cells and how their interactions with neu [...]

A protein’s genetic architecture – the set of causal rules by which its sequence produces its functions – also determines its possible evolutionary trajectories. Prior re [...]