The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve a non-toxigenic Protein A (SpA) variant or an antibody directed thereto.
Details
Title
COMPOSITIONS AND METHODS RELATED TO PROTEIN A (SPA) ANTIBODIES AS AN ENHANCER OF IMMUNE RESPONSE
Inventors
Schneewind, Olaf : University of Chicago Cheng, Alice G. : University of Chicago Missiakas, Dominique M. : University of Chicago Kim, Hwan Keun : University of Chicago