Tregs in transplantation tolerance: Role and therapeutic potential
Cassano, Alexandra; Chong, Anita S.; Alegre, Maria-Luisa
2023

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Abstract

CD4+ Foxp3+ regulatory T cells (Tregs) are indispensable for preventing autoimmunity, and they play a role in cancer and transplantation settings by restraining immune responses. In this review, we describe evidence for the importance of Tregs in the induction versus maintenance of transplantation tolerance, discussing insights into mechanisms of Treg control of the alloimmune response. Further, we address the therapeutic potential of Tregs as a clinical intervention after transplantation, highlighting engineered CAR-Tregs as well as expansion of donor and host Tregs.

Details

Title
Tregs in transplantation tolerance: Role and therapeutic potential
Author
Cassano, Alexandra : University of Chicago
Chong, Anita S. : University of Chicago
Alegre, Maria-Luisa : University of Chicago
Content Type
Article
Published in
Frontiers in Transplantation
Keywords
Identifier(s)
DOI: https://doi.org/10.3389/frtra.2023.1217065
Publication Date
2023-08-30
Language
English
Copyright Statement

© 2023 Cassano, Chong and Alegre

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Record Appears in
Biological Sciences Division > Medicine
Biological Sciences Division > Surgery
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Record Created
2023-09-03

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