A method and apparatus is provided to generate a multiresolution image having at least two regions with different pixel pitches. The multiresolution image is reconstructed using projection data having various pixel pitches corresponding to the pixel pitches of the multiresolution image. By using a higher resolution inside regions of interest (ROIs) in both the image and projection domains and lower resolution outside the ROIs, fast image reconstruction can be performed while avoiding truncation artifacts, which result imaging is limited to an ROI excluding attenuation regions. Further, those regions of greater clinical relevance and greater structural variance within the reconstructed images can be selected to be within the ROIs to improve the clinical benefit of the multiresolution image. The multiresolution image can be reconstructed using an iterative reconstruction method in which the high- and low-resolution regions are uniquely evaluated.