This research illustrates that complex dynamics of gene products enable the creation of any prescribed cellular differentiation patterns. These complex dynamics can take the form of chaotic, stochastic, or noisy chaotic dynamics. Based on this outcome and previous research, it is established that a generic open chemical reactor can generate an exceptionally large number of different cellular patterns. The mechanism of pattern generation is robust under perturbations and it is based on a combination of Turing’s machines, Turing instability and L. Wolpert’s gradients. These results can help us to explain the formidable adaptive capacities of biochemical systems.
Details
Title
Robust morphogenesis by chaotic dynamics
Author
Reinitz, J. : University of Chicago Vakulenko, S. : Russian Academy of Sciences Sudakow, I. : Open University Grigoriev, D. : Université de Lille
Data availability statement
All data generated or analyzed during this study are included in this published article and its supplementary information files.
Funding Information
National Institutes of Health, 2R01 OD010936 National Science Foundation, Division of Physics, PHY-2102906 Natural Science Foundation, DMS-1929348 Natural Science Foundation, PHY-1748958 Gordon and Betty Moore Foundation, 2919.02 Kavli Foundation Ministry of Science and Higher Education of the Russian Federation, 075-15-2022-291
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