2′-O-methylation (N_m) is an abundant RNA modification exists on different mammalian RNA species. However, potential N_m recognition by prot [...]

Describing morphogenesis generally consists in aggregating the multiple high-resolution spatiotemporal processes involved into reproducible low-dimensional morphological [...]

Transfer RNA (tRNA) is the most abundant cellular RNA family in terms of copy numbers. It not only folds into defined structures but also has complex cellular interaction [...]

Cells are enclosed by a membrane bilayer comprised of lipids and proteins. These membranes function to separate the extracellular environment from the internal cellular p [...]

Understanding how protein structure and function are determined by amino acid sequence is fundamental to biochemistry. Evolutionary biochemistry extends the classic seque [...]

Gene expression is a tightly regulated system critical to defining cellular identity. Of the many regulatory components governing gene expression, this thesis looks at [...]

Posttranslational modifications (PTMs) of proteins play critical roles in regulating many cellular events. Antibodies targeting site-specific PTMs are essential tools for [...]

Active biological molecules present a powerful, yet largely untapped, opportunity to impart autonomous regulation of materials. Because these systems can function robustl [...]

Cells evoke the DNA damage checkpoint (DDC) to inhibit mitosis in the presence of DNA double-strand breaks (DSBs) to allow more time for DNA repair. In budding yeast, a s [...]

Phytosulfokine (PSK) is a plant growth-promoting peptide hormone that is perceived by its cell surface receptors PSKR1 and PSKR2 in Arabidopsis. Plants lacking the PSK re [...]

The instant disclosure provides reagent compounds, and antibody and oligonucleotide reagents, for use in a variety of assays, including immunoassays and nucleic acid hybr [...]

Biological organisms experience constantly changing environments, from sudden changes in physiology brought about by feeding, to the regular rising and setting of the Sun [...]

Most eukaryotic genes encode polypeptides that are either obligate members of hetero-stoichiometric complexes or clients of organelle-targeting pathways. Proteins in thes [...]

The heat shock response (HSR) is a cellular stress pathway primarily regulated by the transcription factor Hsf1. Traditionally, Hsf1 activation has been viewed as a simpl [...]

Transfer ribonucleic acid (tRNA) is an essential molecule for protein translation across kingdoms of life. Canonically, tRNA is responsible for carrying the amino acid to [...]

Background: Determining the composition of artifact residues is a central problem in ancient residue metabolomics. This is done by comparing mass spectral features in [...]

The circadian clock of cyanobacteria, which predicts daily environmental changes, typically includes a standard oscillator consisting of proteins KaiA, KaiB, and KaiC. Ho [...]

The human pathogen Pseudomonas aeruginosa, a leading cause of hospital-acquired infections, inhabits and forms sessile antibiotic-resistant communities called biofilms in [...]

Cellular senescence has been increasingly recognized as a hallmark of cancer, reflecting its association with aging and inflammation, its role as a response to deregulate [...]

One aspect of the present invention describes materials and methods of quantitatively measuring the density or percent occupancy of DNA binding proteins such as histones, [...]

The protein translocon at the endoplasmic reticulum comprises the Sec61 translocation channel and numerous accessory factors that collectively facilitate the biogenesis o [...]

Almost all elongator tRNAs (Transfer RNAs) harbor 5-methyluridine 54 and pseudouridine 55 in the T arm, generated by the enzymes TrmA and TruB, respectively, in Escherich [...]

CUX1 is a homeodomain-containing transcription factor that is essential for the development and differentiation of multiple tissues. CUX1 is recurrently mutated or delete [...]

Bundling and crosslinking of actin networks provide cells with tensile strength and mobility and play critical roles in diverse mechanical processes such as wounding heal [...]

Vasodilator-stimulated phosphoprotein (VASP) family proteins play a crucial role in mediating the actin network architecture in the cytoskeleton. The Ena/VASP homology 2 [...]