Methods for treating subjects suffering from acute myeloid leukemia with FLT3 ligand-targeted miR-150 nanoparticles
2024

Files

Abstract

A nanoparticle delivery system designed for sustained delivery of microRNA-150 (miR-150) to FLT3-overexpressing acute myeloid leukemia (AML) cells, the delivery system comprising poly(amidoamine) (PAMAM) dendrimers complexed with miR-150, wherein at least one dendrimer is surface-functionalized with a ligand specific for FLT3 receptor, and methods for treating AML characterized by FLT3-overexpression are provided.

Details

Title
Methods for treating subjects suffering from acute myeloid leukemia with FLT3 ligand-targeted miR-150 nanoparticles
Inventors
Chen, Jianjun : City of Hope
Hong, Seungpyo : University of Illinois at Chicago
Jiang, Xi : City of Hope
Li, Zejuan : University of Chicago
Applicants
University of Cincinnati
The Board of Trustees of the University of Illinois
University of Chicago
Content Type
Patent
Assignees
University of Cincinnati
University of Chicago
The Board of Trustees of the University of Illinois
Language
English
Filing Date
2021-07-14
Publication Date
2024-04-09
Application Number
202117375548
Patent Number
US 11951178 B2
Record Appears in
Physical Sciences Division > Computer Science
All
Record Created
2024-07-25

Actions

PDF

from
to
Export
Download Full History