This mini review examines the current advances and future prospects of chemical approaches in deformable bioelectronics, emphasizing their transformative potential in healthcare and other sectors. The mini review outlines novel fabrication strategies that rely on chemical principles to create adaptable, comfortable, and durable bioelectronic devices that are capable of seamlessly integrating into the dynamic biological environment. The discussion also extends to the integration of innovative device concepts that enhance the outcomes in both sensing and modulation functionalities. Performance-enhancing strategies that use chemistry to refine the sensitivity and precision of these devices are also highlighted. Moreover, the mini review explores the emerging applications of chemically enhanced bioelectronic devices in healthcare, reflecting the potential of this field to revolutionize patient care and improve health monitoring. In the outlook section, this mini review investigates the promising future of transient and living bioelectronics, emphasizing the pivotal role of chemical approaches in their development. It additionally covers the potential of chemical techniques in powering bioelectronic devices using biological systems and discusses the prospective applications of chemically synthesized bioelectronic devices outside of healthcare. While the field has made substantial progress, this mini review also identifies challenges that must be addressed, thus underlining the necessity for continued research and chemical innovation in bioelectronics.