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1.
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Background: Portable ex vivo lung perfusion during lung transplantation is a resource-intensive technology. In light of its increasing use, we evaluated the cost-effec [...]
24 June 2024 |
Public Health Sciences; Surgery |
Article |
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2.
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Multicellular organisms are capable of generating a wide range of different cell types from the same genome through differentiation, during which distinct gene expression [...]
2024-08 |
Genetics, Genomics, and Systems Biology |
Dissertation |
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3.
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No abstract
14 June 2024 |
Pritzker School of Medicine |
Article |
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4.
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Objective: This study used a national insurance claims database to analyze trends in procedural management of Meniere's disease. Study design: Retrospective coh [...]
03 June 2024 |
Surgery |
Article |
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5.
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Cerebral microbleeds (CMBs) are age-related vascular lesions, predisposing patients to a lifetime risk of stroke and cognitive decline. CMBs most commonly occur in the [...]
2024-08 |
Neurobiology |
Dissertation |
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6.
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In Chapter 1, we developed cell-free DNA (cfDNA) biomarkers. Standard-of-care for patients with localized muscle-invasive bladder cancer is neoadjuvant chemotherapy follo [...]
2024-06 |
Interdisciplinary Scientist Training Program |
Dissertation |
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7.
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Checkpoint blockade immunotherapy (CBI) is a cornerstone of modern cancer treatment, but efficacy is not universal, partly due to a wide variation in baseline immune cell [...]
2024-06 |
Immunology |
Dissertation |
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8.
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This work explores how endothelial cells respond to and regulate immune responses, specificallyfocusing on lymphatic endothelial cells and how their interactions with neu [...]
2024-06 |
Biophysical Sciences |
Dissertation |
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9.
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Allergic asthma is an increasing burden in industrialized countries, where treatments are limited to treating symptoms rather than root causes. In recent years, the use o [...]
2024-06 |
Immunology |
Dissertation |
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10.
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This study aimed to elucidate the complex interplay between microbiota diversity, microbial-derived signals, and alloimmune responses in the context of allograft rejectio [...]
2024-06 |
Immunology |
Dissertation |
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11.
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While single-cell "omics" have been critical for the study of human disease, most of these approaches require tissue dissociation, losing important spatial info [...]
2024-06 |
Interdisciplinary Scientist Training Program |
Dissertation |
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12.
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When talking about cancer, a lot of hallmarks can picture it, such as self-sufficiency in growth signals, evading apoptosis, invasion, and metastasis, and so on. However, [...]
2024-06 |
Cancer Biology |
Dissertation |
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13.
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Host-microbiota-pathogen interactions play a key role in determining survival from lethal bacterial infection leading to sepsis. Here we demonstrate that western diet, h [...]
2024-06 |
Immunology |
Dissertation |
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14.
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In the context of developmental biology, puberty emerges as a critical "window of susceptibility," marking a pivotal phase in which the mammary gland undergoes [...]
2024-06 |
Cancer Biology |
Dissertation |
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15.
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This three-parts thesis presents discovery of the molecular mechanisms underpinning hematopoiesis and its dysregulation in cancer. Identifying tumor suppressor genes [...]
2024-06 |
Cancer Biology |
Dissertation |
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16.
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One of the hallmarks of the emergence of hominins is a transition to bipedalism, but debates continue on the importance of arboreal behaviors including climbing trees for [...]
2024-06 |
Integrative Biology |
Dissertation |
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17.
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Loss of dopamine neurons causes motor deterioration in Parkinson's disease patients. We have previously reported that in addition to acute motor impairment, the impaired [...]
2024-06 |
Neurobiology |
Dissertation |
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18.
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To date, over 170 types of modifications have been identified in RNA, in which around 10 types are discovered in mRNA. RNA modifications play important roles in transcrip [...]
2024-06 |
Biochemistry and Molecular Biophysics |
Dissertation |
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19.
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Among other metals, gold nanoparticles (GNPs) play an important role in emerging cancer therapies. The development, safety, and efficacy of these therapies is contingent [...]
2024-06 |
Medical Physics |
Dissertation |
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20.
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Phytosulfokine (PSK) is a plant growth-promoting peptide hormone that is perceived by its cell surface receptors PSKR1 and PSKR2 in Arabidopsis. Plants lacking the PSK re [...]
2024-06 |
Biochemistry and Molecular Biophysics |
Dissertation |
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21.
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G protein-coupled receptors (GPCRs) form the largest superfamily of cell membrane receptors in eukaryotes and are prime targets for therapeutic development. Among them, a [...]
2024-06 |
Biochemistry and Molecular Biophysics |
Dissertation |
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22.
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The overall goal of research was to analyze magnetic resonance imaging (MRI) radiomic features extracted from the non-cystic kidney parenchyma of patients with autosomal [...]
2024-06 |
Medical Physics |
Dissertation |
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23.
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Breast cancer is the most common malignancy and the second leading cause of cancer death among women in the U.S. Although the racial disparities in breast cancer mortalit [...]
2024-06 |
Public Health Sciences |
Dissertation |
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24.
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A fundamental feature of the nervous system is its topographic organization. The motor system, for example, is topographically organized, as the position of motor neuron [...]
2024-06 |
Neurobiology |
Dissertation |
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25.
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Genome-wide association studies (GWAS) have identified hundreds of thousands of associations between genetic variants and human complex traits/diseases. To functionally a [...]
2024-06 |
Public Health Sciences |
Dissertation |
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