|
1.
|
Background: Drosophila female germline stem cells (GSCs) reside adjacent to a cellular niche that secretes Bone Morphogenetic Protein (BMP) ligands and anchor [...]
03 July 2012 |
Development, Regeneration, and Stem Cell Biology; Genetics, Genomics, and Systems Biology; Molecular Genetics and Cell Biology |
Article |
|
|
2.
|
As a skin appendage organ, the hair follicle provides an excellent paradigm to study tissue homeostasis as adult hair follicles continuously undergo cycles of growth (an [...]
2023-12 |
Development, Regeneration, and Stem Cell Biology |
Dissertation |
|
|
3.
|
To become and remain functional, individual neuron types must select during development and maintain throughout life their distinct terminal identity features, such as ex [...]
03 January 2020 |
Development, Regeneration, and Stem Cell Biology; Neurobiology; Neurology |
Article |
|
|
4.
|
The Hippo (Hpo) pathway regulates tissue growth in many animals. Multiple upstream components promote Hpo pathway activity, but the organization of these different inputs [...]
08 February 2021 |
Development, Regeneration, and Stem Cell Biology; Molecular Genetics and Cell Biology |
Article |
|
|
5.
|
Terminal selectors are transcription factors (TFs) that establish during development and maintain throughout life post-mitotic neuronal identity. We previously showed tha [...]
01 October 2020 |
Development, Regeneration, and Stem Cell Biology; Neurobiology |
Article |
|
|
6.
|
Stress fibers (SFs) are actomyosin bundles commonly found in individually migrating cells in culture. However, whether and how cells use SFs to migrate in vivo or collect [...]
23 November 2021 |
Development, Regeneration, and Stem Cell Biology; Molecular Genetics and Cell Biology |
Article |
|
|
7.
|
How circuit wiring is specified is a key question in developmental neurobiology. Previously, using the Drosophila motor system as a model, we found the classic temporal t [...]
11 May 2020 |
Development, Regeneration, and Stem Cell Biology; Molecular Genetics and Cell Biology |
Article |
|
|
8.
|
For a group of cells to migrate together, each cell must couple the polarity of its migratory machinery with that of the other cells in the cohort. Although collective ce [...]
26 September 2022 |
Development, Regeneration, and Stem Cell Biology; Molecular Genetics and Cell Biology |
Article |
|
|
9.
|
During development, transcriptional complexes at enhancers regulate gene expression in complex spatiotemporal patterns. To achieve robust expression without spurious acti [...]
09 November 2018 |
Ben May Department for Cancer Research; Biochemistry and Molecular Biology; Development, Regeneration, and Stem Cell Biology |
Article |
|
|
10.
|
Coordination of cell proliferation and migration is fundamental for life, and its dysregulation has catastrophic consequences, such as cancer. How cell cycle progression [...]
19 April 2022 |
Development, Regeneration, and Stem Cell Biology; Organismal Biology and Anatomy |
Article |
|
|
11.
|
Described herein are methods for treating breast cancer and for providing a prognosis for metastatic-free survival of breast cancer patients. Aspects relate to treating a [...]
19 April 2018 |
Development, Regeneration, and Stem Cell Biology; Ben May Department for Cancer Research; Cancer Biology |
Patent |
|
|
12.
|
Embodiments of the invention are directed to methods of determining the prognosis of a breast cancer patient by evaluating a specified set of genes. Specifically, methods [...]
17 March 2016 |
Ben May Department for Cancer Research; Development, Regeneration, and Stem Cell Biology |
Patent |
|
|
13.
|
Cell state transitions play a pivotal role in the development of multicellular organisms, orchestrating the precise arrangement and abundance of distinct cell types withi [...]
2023-08 |
Development, Regeneration, and Stem Cell Biology |
Dissertation |
|
|
14.
|
Latent TGFβ binding proteins (LTBPs) regulate the extracellular availability of latent TGFβ. LTBP4 was identified as a genetic modifier of muscular dystrophy in mice an [...]
05 May 2016 |
Development, Regeneration, and Stem Cell Biology; Human Genetics; Medicine |
Article |
|
|
15.
|
Genetic disruption of the dystrophin complex produces muscular dystrophy characterized by a fragile muscle plasma membrane leading to excessive muscle degeneration. Two g [...]
24 October 2017 |
Development, Regeneration, and Stem Cell Biology |
Article |
|
|
16.
|
A limited collection of signaling networks and transcriptional effectors directs the full spectrum of cellular behaviors that comprise development. One mechanism to diver [...]
06 November 2017 |
Ben May Department for Cancer Research; Development, Regeneration, and Stem Cell Biology; Genetics, Genomics, and Systems Biology |
Article |
|
|
17.
|
Diverse shapes and patterns observed in nature are the optimal representation for fulfilling an organism's physiological needs and function, and they follow a shared set [...]
2023-06 |
Development, Regeneration, and Stem Cell Biology |
Dissertation |
|
|
18.
|
TBX5 is essential for limb and heart development. Mutations in TBX5 are associated with Holt-Oram syndrome in humans. Due to the teleost specific genome duplication, zebr [...]
10 December 2018 |
Development, Regeneration, and Stem Cell Biology; Organismal Biology and Anatomy |
Article |
|
|
19.
|
The paths axons travel to reach their targets and the subsequent synaptic connections they form are highly stereotyped. How cell surface proteins (CSPs) mediate these pro [...]
21 October 2022 |
Development, Regeneration, and Stem Cell Biology; Molecular Genetics and Cell Biology |
Article |
|
|
20.
|
Atrial fibrillation (AF) is the most common type of cardiac arrhythmia, characterized by an irregular heartbeat due to uncoordinated electrical activity in the atria. The [...]
2022-12 |
Development, Regeneration, and Stem Cell Biology |
Dissertation |
|
|
21.
|
The Hippo pathway is an evolutionarily conserved regulator of tissue growth. At the core of the Hippo pathway, a kinase cascade represses the activity of a transcriptiona [...]
2022-12 |
Development, Regeneration, and Stem Cell Biology |
Dissertation |
|
|
22.
|
Hox transcription factors play fundamental roles during early patterning, but they are also expressed continuously, from embryonic stages through adulthood, in the nervou [...]
2022-08 |
Development, Regeneration, and Stem Cell Biology |
Dissertation |
|
|
23.
|
Our daily life is filled with locomotion and emotion, two processes controlled by our sophisticated and delicate nervous system. During development, billions of neurons m [...]
2022-06 |
Development, Regeneration, and Stem Cell Biology |
Dissertation |
|
|
24.
|
Neural crest (NC) cell development is a complex, multistep process that begins with induction and specification in the region between the neural and non-neural plate, ter [...]
2021-06 |
Development, Regeneration, and Stem Cell Biology |
Dissertation |
|
|
25.
|
Cells use actin-based cytoskeletal arrays to accomplish a variety of tasks, including cell division, cell migration, intracellular trafficking, and multicellular tissue m [...]
2021-03 |
Development, Regeneration, and Stem Cell Biology |
Dissertation |
|
