Development, Regeneration, and Stem Cell Biology

Prehensile arms are among the most remarkable features of the octopus, but little is known about the neural circuitry controlling arm movements. Here, we report on the ce [...]

The highly conserved Notch signaling pathway governs a plethora of cellular processes and developmental transitions. Unlike other cell surface receptors that rely on elab [...]

Background: Drosophila female germline stem cells (GSCs) reside adjacent to a cellular niche that secretes Bone Morphogenetic Protein (BMP) ligands and anchor [...]

As a skin appendage organ, the hair follicle provides an excellent paradigm to study tissue homeostasis as adult hair follicles continuously undergo cycles of growth (an [...]

To become and remain functional, individual neuron types must select during development and maintain throughout life their distinct terminal identity features, such as ex [...]

The Hippo (Hpo) pathway regulates tissue growth in many animals. Multiple upstream components promote Hpo pathway activity, but the organization of these different inputs [...]

Terminal selectors are transcription factors (TFs) that establish during development and maintain throughout life post-mitotic neuronal identity. We previously showed tha [...]

Stress fibers (SFs) are actomyosin bundles commonly found in individually migrating cells in culture. However, whether and how cells use SFs to migrate in vivo or collect [...]

How circuit wiring is specified is a key question in developmental neurobiology. Previously, using the Drosophila motor system as a model, we found the classic temporal t [...]

For a group of cells to migrate together, each cell must couple the polarity of its migratory machinery with that of the other cells in the cohort. Although collective ce [...]

During development, transcriptional complexes at enhancers regulate gene expression in complex spatiotemporal patterns. To achieve robust expression without spurious acti [...]

Coordination of cell proliferation and migration is fundamental for life, and its dysregulation has catastrophic consequences, such as cancer. How cell cycle progression [...]

Described herein are methods for treating breast cancer and for providing a prognosis for metastatic-free survival of breast cancer patients. Aspects relate to treating a [...]

Embodiments of the invention are directed to methods of determining the prognosis of a breast cancer patient by evaluating a specified set of genes. Specifically, methods [...]

Cell state transitions play a pivotal role in the development of multicellular organisms, orchestrating the precise arrangement and abundance of distinct cell types withi [...]

Latent TGFβ binding proteins (LTBPs) regulate the extracellular availability of latent TGFβ. LTBP4 was identified as a genetic modifier of muscular dystrophy in mice an [...]

Genetic disruption of the dystrophin complex produces muscular dystrophy characterized by a fragile muscle plasma membrane leading to excessive muscle degeneration. Two g [...]

A limited collection of signaling networks and transcriptional effectors directs the full spectrum of cellular behaviors that comprise development. One mechanism to diver [...]

Diverse shapes and patterns observed in nature are the optimal representation for fulfilling an organism's physiological needs and function, and they follow a shared set [...]

TBX5 is essential for limb and heart development. Mutations in TBX5 are associated with Holt-Oram syndrome in humans. Due to the teleost specific genome duplication, zebr [...]

The paths axons travel to reach their targets and the subsequent synaptic connections they form are highly stereotyped. How cell surface proteins (CSPs) mediate these pro [...]

Atrial fibrillation (AF) is the most common type of cardiac arrhythmia, characterized by an irregular heartbeat due to uncoordinated electrical activity in the atria. The [...]

The Hippo pathway is an evolutionarily conserved regulator of tissue growth. At the core of the Hippo pathway, a kinase cascade represses the activity of a transcriptiona [...]

Hox transcription factors play fundamental roles during early patterning, but they are also expressed continuously, from embryonic stages through adulthood, in the nervou [...]

Our daily life is filled with locomotion and emotion, two processes controlled by our sophisticated and delicate nervous system. During development, billions of neurons m [...]