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1.
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Experiments have found that diffusion in metabolically active cells is much faster than in dormant cells, especially for large particles. However, the mechanism of this s [...]
07 August 2023 |
Biophysical Sciences |
Article |
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2.
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RNA molecules often play critical roles in assisting the formation of membraneless organelles in eukaryotic cells. Yet, little is known about the organization of RNAs wit [...]
27 March 2024 |
Biochemistry and Molecular Biology; Biological Sciences; Biophysical Sciences; Physics |
Article |
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3.
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Cells must sense and respond to sudden maladaptive environmental changes—stresses—to survive and thrive. Across eukaryotes, stresses such as heat shock trigger conser [...]
11 April 2024 |
Biochemistry and Molecular Biology; Biophysical Sciences; Genetics, Genomics, and Systems Biology; Medicine |
Article |
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4.
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Despite the generally accepted role of the hydrophobic effect as the driving force for folding, many intrinsically disordered proteins (IDPs), including those with hydrop [...]
12 April 2024 |
Biochemistry and Molecular Biology; Biophysical Sciences |
Article |
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5.
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Several physical mechanisms have been proposed to explain allostery in proteins. They differ by the number of internal states that they assume a protein to occupy, leavin [...]
09 November 2023 |
Biochemistry and Molecular Biology; Biophysical Sciences |
Article |
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6.
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Bimolecular condensation plays a role in many cellular processes. Despite considerable progress, a residue-level description of condensates has been lacking as obtaining [...]
21 March 2024 |
Biochemistry and Molecular Biology; Biophysical Sciences |
Article |
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7.
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In active materials, uncoordinated internal stresses lead to emergent long-range flows. An understanding of how the behavior of active materials depends on mesoscopic (hy [...]
02 February 2024 |
Biophysical Sciences; Chemistry; Physics |
Article |
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8.
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Plasmids are extrachromosomal genetic elements that often encode fitness-enhancing features. However, many bacteria carry “cryptic” plasmids that do not confer clear [...]
29 February 2024 |
Biochemistry and Molecular Biology; Biophysical Sciences; Medicine; Microbiology |
Article |
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9.
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Dendritic mechanisms driving input-output transformation in starburst amacrine cells (SACs) are not fully understood. Here, we combine two-photon subcellular voltage and [...]
28 February 2024 |
Biophysical Sciences; Computational Neuroscience; Neurobiology |
Article |
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10.
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To date, effective therapeutic treatments that confer strong attenuation against coronaviruses (CoVs) remain elusive. Among potential drug targets, the helicase of CoVs i [...]
07 January 2022 |
Biophysical Sciences |
Article |
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11.
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Little is understood about the embryonic development of sociality. We screened 1120 known drugs and found that embryonic inhibition of topoisomerase IIα (Top2a) resulted [...]
23 November 2022 |
Biophysical Sciences |
Article |
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12.
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<p>Sediment microbial communities are responsible for a majority of the metabolic activity in river and stream ecosystems. Understanding the dynamics in community s [...]
19 May 2014 |
Biophysical Sciences; Ecology and Evolution; Geophysical Sciences |
Article |
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13.
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<p>Recent advances in DNA sequencing technologies have allowed scientists to probe increasingly complex biological systems, including the diversity of bacteria in t [...]
31 July 2013 |
Biophysical Sciences; Ecology and Evolution; Evolutionary Biology |
Article |
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14.
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<p>Understanding microbial partnerships with the medicinally and economically important crop <em>Cannabis</em> has the potential to affect agricultural [...]
16 June 2014 |
Biophysical Sciences; Ecology and Evolution; Evolutionary Biology |
Article |
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15.
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<p>We have experimentally and computationally defined a set of genes that form a conserved metabolic module in the α-proteobacterium <em>Caulobacter crescent [...]
19 December 2008 |
Biochemistry and Molecular Biology; Biophysical Sciences; Microbiology |
Article |
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16.
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<p>Robust methods for identifying patterns of expression in genome-wide data are important for generating hypotheses regarding gene function. To this end, several a [...]
20 March 2015 |
Biophysical Sciences; Chemistry |
Article |
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17.
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The metabolic activity of microbial communities is central to their role in biogeochemical cycles, human health, and biotechnology. Despite the abundance of sequencing da [...]
19 December 2023 |
Biophysical Sciences; Ecology and Evolution; Physics |
Article |
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18.
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Traditional cultivation approaches in microbiology are labor-intensive, low-throughput, and yield biased sampling of environmental microbes due to ecological and evolutio [...]
17 June 2020 |
Biophysical Sciences; Medicine |
Article |
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19.
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Spatially distributed excitation and inhibition collectively shape a visual neuron’s receptive field (RF) properties. In the direction-selective circuit of the mammalia [...]
07 June 2021 |
Biophysical Sciences; Neurobiology; Organismal Biology and Anatomy |
Article |
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20.
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Members of the SAR11 order Pelagibacterales dominate the surface oceans. Their extensive diversity challenges emerging operational boundaries defined for microbial ’spe [...]
03 September 2019 |
Biophysical Sciences; Medicine |
Article |
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21.
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Heat shock induces a conserved transcriptional program regulated by heat shock factor 1 (Hsf1) in eukaryotic cells. Activation of this heat shock response is triggered by [...]
07 August 2020 |
Biochemistry and Molecular Biology; Biophysical Sciences; Chemistry |
Article |
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22.
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Circadian rhythms are biological oscillations that schedule daily changes in physiology. Outside the laboratory, circadian clocks do not generally free-run but are driven [...]
07 July 2017 |
Biochemistry and Molecular Biology; Biophysical Sciences; Chemistry; Ecology and Evolution; Molecular Genetics and Cell Biology; Physics |
Article |
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23.
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Antibodies are critical components of adaptive immunity, binding with high affinity to pathogenic epitopes. Antibodies undergo rigorous selection to achieve this high aff [...]
10 November 2020 |
Biochemistry and Molecular Biology; Biophysical Sciences; Immunology; Medicine; Pathology |
Article |
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24.
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Seagrasses are important primary producers in oceans worldwide. They live in shallow coastal waters that are experiencing carbon dioxide enrichment and ocean acidificatio [...]
15 November 2023 |
Biophysical Sciences; Ecology and Evolution |
Article |
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25.
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Vascular disease is a leading cause of morbidity and mortality in the United States and globally. Pathological vascular remodeling, such as atherosclerosis and stenosis, [...]
08 December 2021 |
Biophysical Sciences; Medicine |
Article |
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