In this dissertation, I examine how fingerspelled words and core signs in American Sign Language (ASL) reduce as they are repeated. This investigation is motivated by theories of language production that posit that reduction may be shaped not only by reducing articulatory effort, but also by accommodation to an interlocutor's understanding of the linguistic signal. However, the distinct articulatory constraints of different linguistic systems, like those of fingerspelling and core signs in ASL, may allow for different possibilities to reduce articulatory effort. This, in turn may have a distinct impact on an interlocutor’s perception of reduced forms. I first focus on reduction patterns in fingerspelling, using a corpus of fingerspelled words to test not only how gradient reduction in word duration proceeds as fingerspelled words are repeated, but also whether this is accompanied by the deletion of fingerspelled letters. The analysis shows fingerspelling reducing considerably, across multiple mentions, with letter deletions increasing with repetition. In my second analysis, I examine how core signs in ASL reduce across repeated mentions, with results showing not only duration reduction across multiple mentions, but also other types of reduction, including the deletion of movements and the centralization of the location of signs articulated on the body. I then directly compare these two systems, using fingerspelled words and signs from the same corpus to determine whether reduction patterns differ between the two categories. The findings from the language production analysis show strikingly similar patterns in duration reduction between fingerspelling and core signs. Finally, I compare how reduction in each of these systems impacts the perception of reduced forms. Contrasting with the results from the analyses of language production, findings from the perception experiment suggest an unequal impact of reduction in the fingerspelling and core sign systems on how signers of ASL perceive reduction. Together, this adds detail to our understanding of how different articulatory systems influence reduction, as well as shows a disconnect between patterns in the production and perception of reduced forms.