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The effect of the 7R allele at the DRD4 locus on risk tolerance is independent of background risk in Senegalese fishermen

Clochard, Gwen-Jirō; Mbengue, Aby; Mettling, Clément; Diouf, Birane; Faurie, Charlotte; Sene, Omar; Chancerel, Emilie; Guichoux, Erwan; Hollard, Guillaume; Raymond, Michel; Willinger, Marc
2023
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Abstract

It has been shown that living in risky environments, as well as having a risky occupation, can moderate risk-tolerance. Despite the involvement of dopamine in the expectation of reward described by neurobiologists, a GWAS study was not able to demonstrate a genetic contribution of genes involved in the dopaminergic pathway in risk attitudes and gene candidate studies gave contrasting results. We test the possibility that a genetic effect of the DRD4-7R allele in risk-taking behavior could be modulated by environmental factors. We show that the increase in risk-tolerance due to the 7R allele is independent of the environmental risk in two populations in Northern Senegal, one of which is exposed to a very high risk due to dangerous fishing.

Details

Title
The effect of the 7R allele at the DRD4 locus on risk tolerance is independent of background risk in Senegalese fishermen
Author
Clochard, Gwen-Jirō : University of Chicago
Mbengue, Aby : Université Gaston Berger
Mettling, Clément : Université de Montpellier
Diouf, Birane : Université Gaston Berger
Faurie, Charlotte : Université de Montpellier
Sene, Omar : Université Alioune Diop
Chancerel, Emilie : Université de Bordeaux
Guichoux, Erwan : Université de Bordeaux
Hollard, Guillaume : Ecole polytechnique - CREST
Raymond, Michel : Université de Montpellier
Willinger, Marc : Université de Montpellier
Content Type
Article
Published in
Scientific Reports
Identifier(s)
DOI: https://doi.org/10.1038/s41598-022-27002-3
Data availability statement
The data used for this paper are available on the repository of the American Economic Association, under the identifier “openicpsr-179321”, and can be accessed using the following link (login necessary). The sequencing data are registered on the BioProject data base, under the identifier ID PRJNA879442, and are accessible using the following link (embargo until 2023-10-05).
Funding Information
GENES
Key initiatives MUSE Sea & Coast
Investissements d’Avenir, ANR-11-IDEX-0003/Labex Ecodec/ANR-11-LABX-0047
Publication Date
2023-01-12
Language
English
Copyright Statement

© The Author(s) 2023

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Licensing
Record Appears in
Social Sciences Division > Kenneth C. Griffin Department of Economics
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Record Created
2023-01-13

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