The 1990s and early 2000s represented a pivotal period in HIV healthcare marked by the introduction of combination therapies which prompted shifts in healthcare infrastructure, expanded access, and new conversations about what it meant to live with the disease. Simultaneously, emergent discourses grappled with earlier legacies and mythologies of earlier HIV narratives while responding to the realities of new treatments, industrialized healthcare, and the continuation of fragmented access to resources. Together, these discourses reveal how HIV care in Minnesota was continuously shaped by the dialectic between sociocultural understandings and developments to healthcare. This thesis examines the production of HIV treatment from 1985-2012 in Minnesota. It focuses predominantly on the development of pharmaceuticals and changing healthcare landscapes, but also public health messaging, educational programs, and media discourse. It argues HIV must be understood as both a biological condition and complex social entity shaped by cultural, political, and economic systems. Focusing on the late twentieth and early twenty-first centuries, this thesis explores changing definitions of the disease and its treatment pathways as they dialoged with collective memories from earlier times of the epidemic.