This study explores the water-energy-food (WEF) nexus through an industry-focused lens highlighting how innovations in these spaces can go from lab to market. Based on data collected from 70+ customer discovery interviews and literature research, this paper presents interconnected issues, trends, opportunities, challenges, and industry analysis among these three areas. Also detailed are the ramifications of global climate change, the culture inside and outside the WEF, and regulations on innovation in these areas.