The use of low-cost sensors (LCSs) for the mobile monitoring of oil and gas emissions is an understudied application of low-cost air quality monitoring devices. To assess the efficacy of low-cost sensors as a screening tool for the mobile monitoring of fugitive methane emissions stemming from well sites in eastern Colorado, we colocated an array of low-cost sensors (XPOD) with a reference grade methane monitor (Aeris Ultra) on a mobile monitoring vehicle from 15 August through 27 September 2023. Fitting our low-cost sensor data with a bootstrap and aggregated random forest model, we found a high correlation between the reference and XPOD CH₄ concentrations (r = 0.719) and a low experimental error (RMSD = 0.3673 ppm). Other calibration models, including multilinear regression and artificial neural networks (ANN), were either unable to distinguish individual methane spikes above baseline or had a significantly elevated error (RMSD_ANN = 0.4669 ppm) when compared to the random forest model. Using out-of-bag predictor permutations, we found that sensors that showed the highest correlation with methane displayed the greatest significance in our random forest model. As we reduced the percentage of colocation data employed in the random forest model, errors did not significantly increase until a specific threshold (50 percent of total calibration data). Using a peakfinding algorithm, we found that our model was able to predict 80 percent of methane spikes above 2.5 ppm throughout the duration of our field campaign, with a false response rate of 35 percent.