Published February 27, 2024
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Proximity-dependent split RNA polymerases as a versatile biosensor platform
- 1. University of Chicago
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Description
A proximity dependent split T7 RNAP (RNA polymerase) sensor using continuous molecular evolution is described. The versatility of the platform is described by creating robust light and small molecule-responsive genetic sensors. The activity-responsive RNAP platform dramatically simplifies and expands genetic circuit creation, and opens new opportunities in protein engineering, synthetic biology, and bioengineering.
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US_11913081_B2.pdf
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Additional details
Identifiers
- Patent number
- US 11913081 B2
- Patent application number
- 201716305298
- Other
- oai:uchicago.tind.io:11580
Dates
- Patent filed
-
2017-06-06