Social Sciences Division
Published January 12, 2023 | Version v1
Journal article Open

The effect of the 7R allele at the DRD4 locus on risk tolerance is independent of background risk in Senegalese fishermen

Creators

  • 1. University of Chicago
  • 2. Université Gaston Berger
  • 3. Université de Montpellier
  • 4. Université Alioune Diop
  • 5. Université de Bordeaux
  • 6. Ecole polytechnique - CREST

Description

It has been shown that living in risky environments, as well as having a risky occupation, can moderate risk-tolerance. Despite the involvement of dopamine in the expectation of reward described by neurobiologists, a GWAS study was not able to demonstrate a genetic contribution of genes involved in the dopaminergic pathway in risk attitudes and gene candidate studies gave contrasting results. We test the possibility that a genetic effect of the DRD4-7R allele in risk-taking behavior could be modulated by environmental factors. We show that the increase in risk-tolerance due to the 7R allele is independent of the environmental risk in two populations in Northern Senegal, one of which is exposed to a very high risk due to dangerous fishing.

Data availability

The data used for this paper are available on the repository of the American Economic Association, under the identifier "openicpsr-179321", and can be accessed using the following link (login necessary). The sequencing data are registered on the BioProject data base, under the identifier ID PRJNA879442, and are accessible using the following link (embargo until 2023-10-05).

Files

Effect-of-the-7R-allele-at-the-DRD4-locus-on-risk-tolerance.pdf

Files (2.2 MB)

Name Size Download all
Supplementary information
md5:13aabaf8ce86fb2cf78ae06ee7cb535c
1.2 MB Preview Download
Article
md5:5ac2d0e0d5de86ce94ceeee3397921d7
1.0 MB Preview Download

Additional details

Identifiers

DOI
10.1038/s41598-022-27002-3
Other
oai:uchicago.tind.io:5379

Funding

GENES
Key initiatives MUSE Sea & Coast
Investissements d'Avenir
ANR-11-IDEX-0003/Labex Ecodec/ANR-11-LABX-0047

UChicago Information

Division(s)
Social Sciences Division
Department(s)
Kenneth C. Griffin Department of Economics