Published April 9, 2024
| Version v1
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Methods for treating subjects suffering from acute myeloid leukemia with FLT3 ligand-targeted miR-150 nanoparticles
Creators
- 1. City of Hope
- 2. University of Illinois at Chicago
- 3. University of Chicago
Contributors
Description
A nanoparticle delivery system designed for sustained delivery of microRNA-150 (miR-150) to FLT3-overexpressing acute myeloid leukemia (AML) cells, the delivery system comprising poly(amidoamine) (PAMAM) dendrimers complexed with miR-150, wherein at least one dendrimer is surface-functionalized with a ligand specific for FLT3 receptor, and methods for treating AML characterized by FLT3-overexpression are provided.
Files
US_11951178_B2.pdf
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Additional details
Identifiers
- Patent number
- US 11951178 B2
- Patent application number
- 202117375548
- Other
- oai:uchicago.tind.io:12994
Dates
- Patent filed
-
2021-07-14