Published April 13, 2021 | Version v1
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Small molecules inhibitors of RAD51

Description

Embodiments concern methods and small molecule compositions for selectively inhibiting RAD51-mediated D-loop formation while preserving RAD51's ability to form nucleoprotein filaments. The selective RAD51 D-loop formation activity inhibitors DNA repair while minimizing replication-associated toxicity in normal tissue.

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Additional details

Identifiers

Patent number
US 10973819 B2
Patent application number
US 201716081662 A
Other
oai:uchicago.tind.io:7352

Dates

Patent filed
2017-03-02

UChicago Information

Division(s)
Biological Sciences Division
Department(s)
Radiation and Cellular Oncology