Pritzker School of Molecular Engineering
Published March 19, 2015 | Version v1
Patent Open

SYSTEM AND METHOD FOR PRESENTING LARGE DNA MOLECULES FOR ANALYSIS

Creators

  • 1. University of Wisconsin-Madison
  • 2. Leiden University
  • 3. University of Chicago

Contributors

Description

Systems and methods for presenting nucleic acid molecules for analysis are provided. The nucleic acid molecules have a central portion that is contained within a nanoslit. The nanoslit contains an ionic buffer. The nucleic acid molecule has a contour length that is greater than a nanoslit length of the nanoslit. An ionic strength of the ionic buffer and electrostatic or hydrodynamic properties of the nanoslit and the nucleic acid molecule combining to provide a summed Debye length that is greater than or equal to the smallest physical dimension of the nanoslit.

Files

US20150075984.pdf

Files (1.4 MB)

Name Size Download all
md5:74808426b8b51bc4af4652e1839e118e
1.4 MB Preview Download

Additional details

Identifiers

Patent application number
US 201414485119 A
Patent number
US 2015/0075984 A1
Other
oai:uchicago.tind.io:9516

Dates

Patent filed
2014-09-12

UChicago Information

Division(s)
Pritzker School of Molecular Engineering