Biological Sciences Division
Published June 15, 2024 | Version v1
Journal article Open

Evidence from comprehensive independent validation studies for smooth pursuit dysfunction as a sensorimotor biomarker for psychosis

Creators

  • 1. University of Muenster
  • 2. University of Luebeck
  • 3. Ludwig-Maximilian University Munich
  • 4. Heinrich-Heine University
  • 5. Philipps-University Marburg
  • 6. University of Chicago
  • 7. University of Minnesota

Description

Smooth pursuit eye movements are considered a well-established and quantifiable biomarker of sensorimotor function in psychosis research. Identifying psychotic syndromes on an individual level based on neurobiological markers is limited by heterogeneity and requires comprehensive external validation to avoid overestimation of prediction models. Here, we studied quantifiable sensorimotor measures derived from smooth pursuit eye movements in a large sample of psychosis probands (N = 674) and healthy controls (N = 305) using multivariate pattern analysis. Balanced accuracies of 64% for the prediction of psychosis status are in line with recent results from other large heterogenous psychiatric samples. They are confirmed by external validation in independent large samples including probands with (1) psychosis (N = 727) versus healthy controls (N = 292), (2) psychotic (N = 49) and non-psychotic bipolar disorder (N = 36), and (3) non-psychotic affective disorders (N = 119) and psychosis (N = 51) yielding accuracies of 65%, 66% and 58%, respectively, albeit slightly different psychosis syndromes. Our findings make a significant contribution to the identification of biologically defined profiles of heterogeneous psychosis syndromes on an individual level underlining the impact of sensorimotor dysfunction in psychosis.

Notes

Due to the large number of authors, only the first 20 and the University of Chicago authors are included on the above author list. Please download the article for the complete list of authors.

Data availability

The data can be provided by Rebekka Lencer pending scientific review and a completed material transfer agreement. Requests for the data should be submitted to: Rebekka Lencer.

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Additional details

Identifiers

DOI
10.1038/s41598-024-64487-6
Other
oai:uchicago.tind.io:12689

Funding

Projekt DEAL
National Institute of Mental Health
MH103366
National Institute of Mental Health
MH096900
National Institute of Mental Health
MH103368
National Institute of Mental Health
MH077851
National Institute of Mental Health
MH096913
National Institute of Mental Health
MH078113
National Institute of Mental Health
MH096942
National Institute of Mental Health
MH077945
National Institute of Mental Health
MH096957
National Institute of Mental Health
MH077852
National Institute of Mental Health
MH077862
German Research Council (Deutsche Forschungsgemeinschaft, DFG)
KI 588/14-1
German Research Council (Deutsche Forschungsgemeinschaft, DFG)
KI 588/14-2
German Research Council (Deutsche Forschungsgemeinschaft, DFG)
KR 3822/7-1
German Research Council (Deutsche Forschungsgemeinschaft, DFG)
KR 3822/7-2
German Research Council (Deutsche Forschungsgemeinschaft, DFG)
NE 2254/1-2
German Research Council (Deutsche Forschungsgemeinschaft, DFG)
DA 1151/5-1
German Research Council (Deutsche Forschungsgemeinschaft, DFG)
DA 1151/5-2
German Research Council (Deutsche Forschungsgemeinschaft, DFG)
SCHW 559/14-1
German Research Council (Deutsche Forschungsgemeinschaft, DFG)
SCHW 559/14–2
German Research Council (Deutsche Forschungsgemeinschaft, DFG)
WO 1732/4-1
German Research Council (Deutsche Forschungsgemeinschaft, DFG)
WO 1732/4-2
German Research Council (Deutsche Forschungsgemeinschaft, DFG)
AL 1145/5-2
German Research Council (Deutsche Forschungsgemeinschaft, DFG)
CU 43/9-2
German Research Council (Deutsche Forschungsgemeinschaft, DFG)
GA 545/7-2
German Research Council (Deutsche Forschungsgemeinschaft, DFG)
RI 908/11-2
German Research Council (Deutsche Forschungsgemeinschaft, DFG)
WI 3439/3-2
German Research Council (Deutsche Forschungsgemeinschaft, DFG)
NO 246/10-2
German Research Council (Deutsche Forschungsgemeinschaft, DFG)
DE 1614/3-2
German Research Council (Deutsche Forschungsgemeinschaft, DFG)
HA 7070/2-2
German Research Council (Deutsche Forschungsgemeinschaft, DFG)
JA 1890/7-1
German Research Council (Deutsche Forschungsgemeinschaft, DFG)
JA 1890/7-2
German Research Council (Deutsche Forschungsgemeinschaft, DFG)
MU 1315/8-2
German Research Council (Deutsche Forschungsgemeinschaft, DFG)
RE 737/20-2
German Research Council (Deutsche Forschungsgemeinschaft, DFG)
PF 784/1-2
German Research Council (Deutsche Forschungsgemeinschaft, DFG)
KI 588/17-1
German Research Council (Deutsche Forschungsgemeinschaft, DFG)
CU 43/9-1
EU-FP7-HEALTH
602152
University of Münster
Innovative Medical Research
German Research Council (Deutsche Forschungsgemeinschaft, DFG)
LE 1122/7-1

UChicago Information

Division(s)
Biological Sciences Division
Department(s)
Psychiatry and Behavioral Neuroscience