Published November 8, 2018
| Version v1
Journal article
Open
The genetic prehistory of the Andean highlands 7000 years BP though European contact
Creators
- 1. University of Chicago
- 2. University of California, Davis
- 3. University of Oklahoma
- 4. Universidad de Chile
- 5. University of Arizona
- 6. Peruvian Register of Professional Archaeologists
- 7. Case Western University
- 8. University of California, Merced
Description
The peopling of the Andean highlands above 2500 m in elevation was a complex process that included cultural, biological, and genetic adaptations. Here, we present a time series of ancient whole genomes from the Andes of Peru, dating back to 7000 calendar years before the present (BP), and compare them to 42 new genome-wide genetic variation datasets from both highland and lowland populations. We infer three significant features: A split between low- And high-elevation populations that occurred between 9200 and 8200 BP; a population collapse after European contact that is significantly more severe in South American lowlanders than in highland populations; and evidence for positive selection at genetic loci related to starch digestion and plausibly pathogen resistance after European contact. We do not find selective sweep signals related to known components of the human hypoxia response, which may suggest more complex modes of genetic adaptation to high altitude.
Data availability
All data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials. Additional data related to this paper may be requested from the authors. Ancient and modern DNA sequences are available from NCBI Sequence Read Archive, accession no. PRJNA470966. The Huilliche-Pehuenche SNP data will be available via a data access agreement with R.A.V. at the Universidad de Chile.Files
sciadv.aau4921.pdf
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Additional details
Identifiers
- DOI
- 10.1126/sciadv.aau4921
- Other
- oai:uchicago.tind.io:11063
Funding
- National Science Foundation
- BCS-1528698
- National Science Foundation
- BCS-1311626
- National Science Foundation
- SBR-9816313
- National Science Foundation
- SBR-9978006
- National Institutes of Health
- R01HL119577
- National Geographic Society
- 5245-94