@article{TEXTUAL,
      recid = {9918},
      author = {Fair, Benjamin Jung and Blake, Lauren E. and Sarkar,  Abhishek and Pavlovic, Bryan J. and Cuevas, Claudia and  Gilad, Yoav},
      title = {Gene expression variability in human and chimpanzee  populations share common determinants},
      journal = {eLife},
      address = {2020-10-21},
      number = {TEXTUAL},
      abstract = {Inter-individual variation in gene expression has been  shown to be heritable and is often associated with  differences in disease susceptibility between individuals.  Many studies focused on mapping associations between  genetic and gene regulatory variation, yet much less  attention has been paid to the evolutionary processes that  shape the observed differences in gene regulation between  individuals in humans or any other primate. To begin  addressing this gap, we performed a comparative analysis of  gene expression variability and expression quantitative  trait loci (eQTLs) in humans and chimpanzees, using gene  expression data from primary heart samples. We found that  expression variability in both species is often determined  by non-genetic sources, such as cell-type heterogeneity.  However, we also provide evidence that inter-individual  variation in gene regulation can be genetically controlled,  and that the degree of such variability is generally  conserved in humans and chimpanzees. In particular, we  found a significant overlap of orthologous genes associated  with eQTLs in both species. We conclude that gene  expression variability in humans and chimpanzees often  evolves under similar evolutionary pressures.},
      url = {http://knowledge.uchicago.edu/record/9918},
}