@article{TEXTUAL,
      recid = {9909},
      author = {Meng, Julia L. and Wang, Yupu and Carrillo, Robert A. and  Heckscher, Ellie S.},
      title = {Temporal transcription factors determine circuit  membership by permanently altering motor neuron-to-muscle  synaptic partnerships},
      journal = {eLife},
      address = {2020-05-11},
      number = {TEXTUAL},
      abstract = {How circuit wiring is specified is a key question in  developmental neurobiology. Previously, using the  Drosophila motor system as a model, we found the classic  temporal transcription factor Hunchback acts in NB7-1  neuronal stem cells to control the number of NB7-1 neuronal  progeny form functional synapses on dorsal muscles (Meng et  al., 2019). However, it is unknown to what extent control  of motor neuron-to-muscle synaptic partnerships is a  general feature of temporal transcription factors. Here, we  perform additional temporal transcription factor  manipulations—prolonging expression of Hunchback in NB3-1,  as well as precociously expressing Pdm and Castor in NB7-1.  We use confocal microscopy, calcium imaging, and  electrophysiology to show that in every manipulation there  are permanent alterations in neuromuscular synaptic  partnerships. Our data show temporal transcription factors,  as a group of molecules, are potent determinants of  synaptic partner choice and therefore ultimately control  circuit membership.},
      url = {http://knowledge.uchicago.edu/record/9909},
}