@article{TEXTUAL,
      recid = {9905},
      author = {Triandafillou, Catherine G. and Katanski, Christopher D.  and Dinner, Aaron R. and Allan Drummond, D.},
      title = {Transient intracellular acidification regulates the core  transcriptional heat shock response},
      journal = {eLife},
      address = {2020-08-07},
      number = {TEXTUAL},
      abstract = {Heat shock induces a conserved transcriptional program  regulated by heat shock factor 1 (Hsf1) in eukaryotic  cells. Activation of this heat shock response is triggered  by heat-induced misfolding of newly synthesized  polypeptides, and so has been thought to depend on ongoing  protein synthesis. Here, using the budding yeast  Saccharomyces cerevisiae, we report the discovery that Hsf1  can be robustly activated when protein synthesis is  inhibited, so long as cells undergo cytosolic  acidification. Heat shock has long been known to cause  transient intracellular acidification which, for reasons  which have remained unclear, is associated with increased  stress resistance in eukaryotes. We demonstrate that  acidification is required for heat shock response induction  in translationally inhibited cells, and specifically  affects Hsf1 activation. Physiological heat-triggered  acidification also increases population fitness and  promotes cell cycle reentry following heat shock. Our  results uncover a previously unknown adaptive dimension of  the well-studied eukaryotic heat shock response.},
      url = {http://knowledge.uchicago.edu/record/9905},
}