TY  - GEN
AB  - Gene expression noise is an evolvable property of biological systems that describes differences in expression among genetically identical cells in the same environment. Prior work has shown that expression noise is heritable and can be shaped by selection, but the impact of variation in expression noise on organismal fitness has proven difficult to measure. Here, we quantify the fitness effects of altering expression noise for the TDH3 gene in Saccharomyces cerevisiae. We show that increases in expression noise can be deleterious or beneficial depending on the difference between the average expression level of a genotype and the expression level maximizing fitness. We also show that a simple model relating single-cell expression levels to population growth produces patterns consistent with our empirical data. We use this model to explore a broad range of average expression levels and expression noise, providing additional insight into the fitness effects of variation in expression noise. 
AD  - University of Michigan
AD  - University of Michigan
AD  - University of Chicago
AD  - University of Michigan
AD  - University of Michigan
AD  - University of Michigan
AD  - University of Michigan
AD  - University of Michigan
AU  - Duveau, Fabien
AU  - Hodgins-Davis, Andrea
AU  - Metzger, Brian P. H.
AU  - Yang, Bing
AU  - Tryban, Stephen
AU  - Walker, Elizabeth A.
AU  - Lybrook, Tricia
AU  - Wittkopp, Patricia J.
DA  - 2018-08-20
ID  - 9902
JF  - eLife
KW  - gene expression
KW  - promoter
KW  - TDH3
KW  - evolution
KW  - selection
KW  - competitive growth
L1  - https://knowledge.uchicago.edu/record/9902/files/elife-37272-v2.pdf
L1  - https://knowledge.uchicago.edu/record/9902/files/elife-37272.zip
L2  - https://knowledge.uchicago.edu/record/9902/files/elife-37272-v2.pdf
L2  - https://knowledge.uchicago.edu/record/9902/files/elife-37272.zip
L4  - https://knowledge.uchicago.edu/record/9902/files/elife-37272-v2.pdf
L4  - https://knowledge.uchicago.edu/record/9902/files/elife-37272.zip
LA  - eng
LK  - https://knowledge.uchicago.edu/record/9902/files/elife-37272-v2.pdf
LK  - https://knowledge.uchicago.edu/record/9902/files/elife-37272.zip
N2  - Gene expression noise is an evolvable property of biological systems that describes differences in expression among genetically identical cells in the same environment. Prior work has shown that expression noise is heritable and can be shaped by selection, but the impact of variation in expression noise on organismal fitness has proven difficult to measure. Here, we quantify the fitness effects of altering expression noise for the TDH3 gene in Saccharomyces cerevisiae. We show that increases in expression noise can be deleterious or beneficial depending on the difference between the average expression level of a genotype and the expression level maximizing fitness. We also show that a simple model relating single-cell expression levels to population growth produces patterns consistent with our empirical data. We use this model to explore a broad range of average expression levels and expression noise, providing additional insight into the fitness effects of variation in expression noise. 
PY  - 2018-08-20
T1  - Fitness effects of altering gene expression noise in <i>Saccharomyces cerevisiae</i>
TI  - Fitness effects of altering gene expression noise in <i>Saccharomyces cerevisiae</i>
UR  - https://knowledge.uchicago.edu/record/9902/files/elife-37272-v2.pdf
UR  - https://knowledge.uchicago.edu/record/9902/files/elife-37272.zip
Y1  - 2018-08-20
ER  -