@article{TEXTUAL,
      recid = {9895},
      author = {Tejedor-Sanz, Sara and Stevens, Eric T. and Li, Siliang  and Finnegan, Peter and Nelson, James and Knoesen, Andre  and Light, Samuel H. and Ajo-Franklin, Caroline M. and  Marco, Maria L.},
      title = {Extracellular electron transfer increases fermentation in  lactic acid bacteria via a hybrid metabolism},
      journal = {eLife},
      address = {2022-02-11},
      number = {TEXTUAL},
      abstract = {Energy conservation in microorganisms is classically  categorized into respiration and fermentation; however,  recent work shows some species can use mixed or alternative  bioenergetic strategies. We explored the use of  extracellular electron transfer for energy conservation in  diverse lactic acid bacteria (LAB), microorganisms that  mainly rely on fermentative metabolism and are important in  food fermentations. The LAB Lactiplantibacillus plantarum  uses extracellular electron transfer to increase its  NAD+/NADH ratio, generate more ATP through substrate-level  phosphorylation, and accumulate biomass more rapidly. This  novel, hybrid metabolism is dependent on a type-II NADH  dehydrogenase (Ndh2) and conditionally requires a  flavin-binding extracellular lipoprotein (PplA) under  laboratory conditions. It confers increased fermentation  product yield, metabolic flux, and environmental  acidification in laboratory media and during kale juice  fermentation. The discovery of a single pathway that  simultaneously blends features of fermentation and  respiration in a primarily fermentative microorganism  expands our knowledge of energy conservation and provides  immediate biotechnology applications.},
      url = {http://knowledge.uchicago.edu/record/9895},
}