@article{TEXTUAL,
      recid = {9840},
      author = {Alhashem, Zain and Feldner-Busztin, Dylan and Revell,  Christopher and Alvarez-Garcillan Portillo, Macarena and  Camargo-Sosa, Karen and Richardson, Joanna and Rocha,  Manuel and Gauert, Anton and Corbeaux, Tatianna and  Milanetto, Martina and Argenton, Francesco and Tiso,  Natascia and Kelsh, Robert N. and Prince, Victoria E. and  Bentley, Katie and Linker, Claudia},
      title = {Notch controls the cell cycle to define leader versus  follower identities during collective cell migration},
      journal = {eLife},
      address = {2022-04-19},
      number = {TEXTUAL},
      abstract = {Coordination of cell proliferation and migration is  fundamental for life, and its dysregulation has  catastrophic consequences, such as cancer. How cell cycle  progression affects migration, and vice versa, remains  largely unknown. We address these questions by combining in  silico modelling and in vivo experimentation in the  zebrafish trunk neural crest (TNC). TNC migrate  collectively, forming chains with a leader cell directing  the movement of trailing followers. We show that the  acquisition of migratory identity is autonomously  controlled by Notch signalling in TNC. High Notch activity  defines leaders, while low Notch determines followers.  Moreover, cell cycle progression is required for TNC  migration and is regulated by Notch. Cells with low Notch  activity stay longer in G1 and become followers, while  leaders with high Notch activity quickly undergo G1/S  transition and remain in S-phase longer. In conclusion, TNC  migratory identities are defined through the interaction of  Notch signalling and cell cycle progression.},
      url = {http://knowledge.uchicago.edu/record/9840},
}