@article{TEXTUAL,
      recid = {9787},
      author = {Bhuiyan, Mohammed and Souris, Jeffrey and Kucharski, Anna  and Freifelder, Richard and Mukherjee, Jogeshwar and Chen,  Chin-Tu},
      title = {A simplified protocol for the automated production of  2-[<sup>18</sup>F]fluoro-3-[2-((S)-3-pyrrolinyl)methoxy]pyridine  ([<sup>18</sup>F]nifene) on an IBA Synthera®  module},
      journal = {Journal of Labelled Compounds and Radiopharmaceuticals},
      address = {2023-11-05},
      number = {TEXTUAL},
      abstract = {The α4β2 nicotinic acetylcholine receptor (nAChR) ligand  2-[<sup>18</sup>F]fluoro-3-[2-((S)-3-pyrrolinyl)methoxy]pyridine  ([<sup>18</sup>F]nifene) has been synthesized in 10%  decay-corrected radiochemical yield using the IBA Synthera®  platform (IBA Cyclotron Solutions, Louvain-la-Neuve,  Belgium) with an integrated fluidic processor (IFP).  Boc-nitronifene served as the precursor, and 20%  trifluoroacetic acid (TFA) was used to deprotect the  Boc-group after radiolabeling. By omitting the solvent  extraction step after radiolabeling, the process was  simplified to a single step with no manual intervention.  [<sup>18</sup>F]Nifene was obtained in decay-corrected  radiochemical yields of 10 ± 2% (n = 20) and radiochemical  purity >99%. Typical specific radioactivities of  2700–4865 mCi/μmole (100–180 GBq/μmol) were measured at the  end of synthesis; total synthesis times were about 1 h  40 min.},
      url = {http://knowledge.uchicago.edu/record/9787},
}