@article{TEXTUAL,
      recid = {9708},
      author = {Ostrosky, Feggy and Decety, Jean and Lozano, Azucena and  Lujan, Angélica and Perez, Martha and Munguia, Ana and  Castañeda, Dianela and Diaz, Karla and Lara, Rafael and  Sacristan, Emilio and Bobes, Maria A. and Borja, Karina and  Camarena, Beatriz and Hernández-Muñoz, Sandra and Álvarez,  Aurora and Franco-Bourland, Rebecca E.},
      title = {Can psychopathy be prevented? Clinical, neuroimaging, and  genetic data: An exploratory study},
      journal = {Child Neuropsychology},
      address = {2023-11-10},
      number = {TEXTUAL},
      abstract = {The aim of the study was to explore the relationship among  brain functional activations elicited by an emotional  paradigm, clinical scores (PTSD, anxiety, and depression),  psychopathic traits, and genetic characteristics (5-HTTLPR)  in a group of severely maltreated children compared to a  healthy control group before and after the implementation  of a Trauma Focused-Cognitive Behavioral Therapy. The final  sample consisted of an experimental group of 14 maltreated  children (mean age = 8.77 years old, S.D. = 1.83) recruited  from a non-governmental shelter in Mexico City for children  who had experienced child abuse and a control group of 10  children from the general population (mean age = 9.57 years  old, S.D. = 1.91). Both groups were matched according to  age and gender and were assessed before and after the  implementation of the aforementioned therapy by means of  clinical scales and an emotional paradigm that elicited  brain activations which were recorded through functional  magnetic resonance imaging. Genotyping of the 5-HTTLPR  polymorphism was made at first assessment. A region of  interest analysis showed amygdala hyperactivation during  exposure to fear and anger stimuli in the maltreated  children before treatment. Following therapy, a decrease in  brain activity as well as a decrease in clinical symptoms  were also observed. 5-HTTLPR polymorphism did not show any  effect on the severity of clinical symptoms in maltreated  children. Trauma-Focused Behavioral Therapy may help  reorganize the brain’s processing of emotional stimuli.  These observations reveal the importance of an early  intervention when the mechanisms of neuroplasticity may be  still recruited.},
      url = {http://knowledge.uchicago.edu/record/9708},
}