@article{TEXTUAL,
      recid = {9706},
      author = {Liu, Bin and Xin, Wang and Tan, Jian-Rong and Zhu,  Rui-Ping and Li, Ting and Wang, Dan and Kan, Sha-Sha and  Xiong, Ding-Kui and Li, Huan-Huan and Zhang, Meng-Meng and  Sun, Huan-Huan and Wagstaff, William and Zhou, Chan and  Wang, Zhi-Jian and Zhang, Yao-Guang and He, Tong-Chuan},
      title = {Myelin sheath structure and regeneration in peripheral  nerve injury repair},
      journal = {PNAS},
      address = {2019-10-14},
      number = {TEXTUAL},
      abstract = {Observing the structure and regeneration of the myelin  sheath in peripheral nerves following injury and during  repair would help in understanding the pathogenesis and  treatment of neurological diseases caused by an abnormal  myelin sheath. In the present study, transmission electron  microscopy, immunofluorescence staining, and transcriptome  analyses were used to investigate the structure and  regeneration of the myelin sheath after end-to-end  anastomosis, autologous nerve transplantation, and nerve  tube transplantation in a rat model of sciatic nerve  injury, with normal optic nerve, oculomotor nerve, sciatic  nerve, and Schwann cells used as controls. The results  suggested that the double-bilayer was the structural unit  that constituted the myelin sheath. The major feature  during regeneration was the compaction of the myelin  sheath, wherein the distance between the 2 layers of cell  membrane in the double-bilayer became shorter and the  adjacent double-bilayers tightly closed together and formed  the major dense line. The expression level of myelin basic  protein was positively correlated with the formation of the  major dense line, and the compacted myelin sheath could not  be formed without the anchoring of the lipophilin particles  to the myelin sheath.},
      url = {http://knowledge.uchicago.edu/record/9706},
}