000009644 001__ 9644 000009644 005__ 20240523043519.0 000009644 02470 $$ahttps://doi.org/10.1016/j.dcn.2023.101320$$2doi 000009644 037__ $$bArticle 000009644 037__ $$aTEXTUAL 000009644 041__ $$aeng 000009644 245__ $$aHooked on a thought: Associations between rumination and neural responses to social rejection in adolescent girls 000009644 269__ $$a2023-10-30 000009644 336__ $$aArticle 000009644 520__ $$aRumination is a significant risk factor for psychopathology in adolescent girls and is associated with heightened and prolonged physiological arousal following social rejection. However, no study has examined how rumination relates to neural responses to social rejection in adolescent girls; thus, the current study aimed to address this gap. Adolescent girls (N = 116; ages 16.95–19.09) self-reported on their rumination tendency and completed a social evaluation fMRI task where they received fictitious feedback (acceptance, rejection) from peers they liked or disliked. Rejection-related neural activity and subgenual anterior cingulate cortex (sgACC) connectivity were regressed on rumination, controlling for rejection sensitivity and depressive symptoms. Rumination was associated with distinctive neural responses following rejection from liked peers including increased neural activity in the precuneus, inferior parietal gyrus, dorsolateral prefrontal cortex, and supplementary motor area (SMA) and reduced sgACC connectivity with multiple regions including medial prefrontal cortex, precuneus and ventrolateral prefrontal cortex. Greater precuneus and SMA activity mediated the effect of rumination on slower response time to report emotional state after receiving rejection from liked peers. These findings provide clues for distinctive cognitive processes (e.g., mentalizing, conflict processing, memory encoding) following the receipt of rejection in girls with high levels of rumination. 000009644 536__ $$oNational Institutes of Health$$cR01MH125873 000009644 536__ $$oNational Institutes of Health$$cR01MH093650 000009644 536__ $$oNational Institutes of Health$$cR01MH066167 000009644 536__ $$oNational Institutes of Health$$cR03MH116519 000009644 536__ $$oNational Institutes of Health$$cR01MH056630 000009644 540__ $$a<p>© 2023 The Authors</p> <p>This is an open access article under the CC BY-NC-ND license (<a href="https://creativecommons.org/licenses/by-nc-nd/4.0/" target="_blank">https://creativecommons.org/licenses/by-nc-nd/4.0/</a>).</p> 000009644 542__ $$fCC BY-NC-ND 000009644 594__ $$aUnthresholded statistical maps were uploaded to NeuroVault.org database and are available at <a href="https://neurovault.org/collections/SHFXELFH/" target="_blank">https://neurovault.org/collections/SHFXELFH/</a>. Data will be freely distributed following a data use request protocol to qualified academic investigators for noncommercial research. Data will be shared in a format that protects the anonymity and privacy of participants. 000009644 6531_ $$aRumination 000009644 6531_ $$aAdolescence 000009644 6531_ $$aSocial rejection 000009644 6531_ $$afMRI 000009644 6531_ $$asgACC 000009644 6531_ $$aDefault mode network 000009644 690__ $$aBiological Sciences Division 000009644 691__ $$aPsychiatry and Behavioral Neuroscience 000009644 7001_ $$1https://orcid.org/0000-0001-9744-553X$$2ORCID$$aYoon, Leehyun$$uUniversity of California, Davis 000009644 7001_ $$aKeenan, Kate E.$$uUniversity of Chicago 000009644 7001_ $$aHipwell, Alison E.$$uUniversity of Pittsburgh 000009644 7001_ $$aForbes, Erika E.$$uUniversity of Pittsburgh 000009644 7001_ $$aGuyer, Amanda E.$$uUniversity of California, Davis 000009644 773__ $$tDevelopmental Cognitive Neuroscience 000009644 8564_ $$yArticle$$905035e17-b6e6-4b9a-a0f2-c401ba0a671d$$s4043775$$uhttps://knowledge.uchicago.edu/record/9644/files/Hooked-on-a-thought.pdf$$ePublic 000009644 8564_ $$ySupplementary material$$941237aa1-f4ae-4daf-a622-eb2e4a5ca209$$s881431$$uhttps://knowledge.uchicago.edu/record/9644/files/1-s2.0-S1878929323001251-mmc1.docx$$ePublic 000009644 908__ $$aI agree 000009644 909CO $$ooai:uchicago.tind.io:9644$$pGLOBAL_SET 000009644 983__ $$aArticle