@article{PATENT,
      recid = {9152},
      title = {Use of continuous/contiguous stacking hybridization as a  diagnostic tool},
      number = {PATENT},
      month = {Jul},
      year = {2000},
      abstract = {A method for detecting disease-associated alleles in  patient genetic material is provided whereby a first group  of oligonucleotide molecules, synthesized to compliment  base sequences of the disease associated alleles is  immobilized on a predetermined position on a substrate, and  then contacted with patient genetic material to form  duplexes. The duplexes are then contacted with a second  group of oligonucleotide molecules which are synthesized to  extend the predetermined length of the oligonucleotide  molecules of the first group, and where each of the  oligonucleotide molecules of the second group are tagged  and either incorporate universal bases or a mixture of  guanine, cytosine, thymine, and adenine, or complementary  nucleotide strands that are tagged with a different  fluorochrome which radiates light at a predetermined  wavelength. The treated substrate is then washed and the  light patterns radiating therefrom are compared with  predetermined light patterns of various diseases that were  prepared on identical substrates. A method is also provided  for determining the length of a repeat sequence in DNA or  RNA, and also for determining the base sequence of unknown  DNA or RNA.},
      url = {http://knowledge.uchicago.edu/record/9152},
}