@article{PATENT,
      recid = {9025},
      title = {Automated method and system for the evaluation of disease  and registration accuracy in the subtraction of temporally  sequential medical images},
      number = {PATENT},
      month = {May},
      year = {2005},
      abstract = {An apparatus, method and computer program product for  performing computer aided diagnosis on temporal subtraction  images of objects. A mode of a gray-level histogram is  identified, and a gray-level threshold is established at a  predefined fraction of this modal value. All pixels with  gray levels below this threshold that lie within the lung  regions of the temporal subtraction image remain "on,"  while all other pixels are set to zero. Area and  circularity requirements are imposed to eliminate  false-positive regions. Areas of pathologic change  identified in this manner may be presented as outlines in  the subtraction image or as highlighted regions in the  original radiographic image so that, in effect, temporal  subtraction becomes a "background" process for  computer-aided diagnosis. The present invention is also  directed to method, apparatus, and computer program product  for performing temporal subtraction on energy subtraction  images, with or without subsequent computer aided  diagnosis, of objects.},
      url = {http://knowledge.uchicago.edu/record/9025},
}