@article{PATENT, recid = {8613}, title = {Double stranded nucleic acid biochips}, number = {PATENT}, month = {May}, year = {2006}, abstract = {This invention describes a new method of constructing double-stranded DNA (dsDNA) microarrays based on the use of pre-synthesized or natural DNA duplexes without a stem-loop structure. The complementary oligonucleotide chains are bonded together by a novel connector that includes a linker for immobilization on a matrix. A non-enzymatic method for synthesizing double-stranded nucleic acids with this novel connector enables the construction of inexpensive and robust dsDNA/dsRNA microarrays. DNA-DNA and DNA-protein interactions are investigated using the microarrays.}, url = {http://knowledge.uchicago.edu/record/8613}, }